Urokinase Plasminogen Activator Receptor (uPAR, CD87) (PE) | MyBioSource MBS600169 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Urokinase Plasminogen Activator Receptor (uPAR, CD87) (PE)

catalog :

MBS600169

quantity :

100 Tests

price :

685 USD

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

[8B52]

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS600169

products type :

Antibody

products full name :

Urokinase Plasminogen Activator Receptor (uPAR, CD87) (PE)

products short name :

[Urokinase Plasminogen Activator Receptor]

products name syn :

[Anti -Urokinase Plasminogen Activator Receptor (uPAR, CD87) (PE)]

other names :

[urokinase plasminogen activator receptor; Urokinase plasminogen activator surface receptor; urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; plasminogen activator, urokinase receptor; Monocyte activation antigen Mo3]

other gene names :

[PLAUR; PLAUR; CD87; UPAR; URKR; U-PAR; MO3; UPAR]

uniprot entry name :

UPAR_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[8B52]

host :

Mouse

reactivity :

Human

specificity :

Recognizes human uPAR. When used in a sandwich ELISA in combination with MBS600169, no significant cross-reactivity was observed with recombinant mouse uPAR.

purity :

Purified. Purified by Protein G affinity chromatography.

form :

Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide.

concentration :

0.025mg/ml

storage stability :

Store product at 4 degree C in the dark. Do Not Freeze! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to emmediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

app notes :

Suitable for use in Flow Cytometry. Dilution: Flow Cytometry: Neat. Use 10ul per 1x10e6 cells using human perripheral blood granulocytes. Optimal dilution to be determined by the researcher.

other info1 :

Immunogen: Recombinant protein corresponding to aa 23-303 from human uPAR (Q03405), expressed in NSO cells.

other info2 :

Control No.: C14121852.

products categories :

Antibodies; Abs to Cancer Markers

products description :

Designed to determine the percentage of cells expressing cell surface CD87 and the density of this protein on cell surfaces by flow cytometry.

ncbi gi num :

433901

uniprot acc num :

Q03405

ncbi mol weight :

36,978 Da

ncbi pathways :

Arf6 Downstream Pathway (138038); Attachment Of GPI Anchor To UPAR Pathway (106239); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Dissolution Of Fibrin Clot Pathway (106061); FGF Signaling Pathway (137989); Hemostasis Pathway (106028); Metabolism Of Proteins Pathway (106230); Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway (106236)

ncbi summary :

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]

uniprot summary :

uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 19q13. Cellular Component: endoplasmic reticulum membrane; focal adhesion; extrinsic to membrane; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane. Molecular Function: protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor activity; receptor binding. Biological Process: fibrinolysis; cellular protein metabolic process; regulation of proteolysis; attachment of GPI anchor to protein; C-terminal protein lipidation; cell motility; signal transduction; blood coagulation; chemotaxis; post-translational protein modification

size1 :

100 Tests

price1 :

685 USD

more info or order :

MyBioSource product webpage