product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mast Cell Chymase
catalog :
MBS600099
quantity :
0.1 mg
price :
630 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[2Q1505]
reactivity :
human
application :
immunohistochemistry, other
more info or order :
image
image 1 :
High magnification: Paraffin-embedded human skin tissue was prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:100 dilution of MBS600099. Cells lining up under the epidermis consist of numerous mast cells (The dermis has a moderate diffuse inflammatory cell infiltrate).
product information
catalog number :
MBS600099
products type :
Antibody
products full name :
Mast Cell Chymase
products short name :
[Mast Cell Chymase]
products name syn :
[Mouse anti-Human Mast Cell Chymase]
other names :
[mast cell chymase; Chymase; chymase; alpha-chymase; chymase, heart; OTTHUMP00000178751; chymase, mast cell; mast cell protease I; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; Alpha-chymase; Mast cell protease I]
other gene names :
[CMA1; CMA1; CYH; MCT1; chymase; MGC119890; MGC119891; CYH; CYM]
uniprot entry name :
CMA1_HUMAN
clonality :
Monoclonal
isotype :
IgG1,k
clone :
[2Q1505]
host :
Mouse
reactivity :
Human
specificity :
Recognizes human mast cell chymase (27kD)
purity :
Purified by Protein G affinity chromatography
form :
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide
concentration :
1 mg/ml
storage stability :
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
tested application :
Immunohistochemistry (IHC). Not suitable for use in formaldehyde fixed tissue. Other applications have not been tested.
app notes :
Immunohistochemistry (paraffin): 1:100. Heat induced epitope retrieval with citrate buffer, pH 6.0 is recommended. Optimal dilutions to be determined by researcher.
image1 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Purified Mast Cell Chymase from human skin. Positive Control: Human skin tissue. Grade: Affinity purified
products categories :
Antibodies; Abs to Cell Markers
ncbi gi num :
180542
ncbi acc num :
NP_001827
uniprot acc num :
P23946
ncbi mol weight :
27kD
ncbi pathways :
ACE Inhibitor Pathway (198763); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486)
ncbi summary :
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq]
uniprot summary :
CMA1: Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Belongs to the peptidase S1 family. Granzyme subfamily. Protein type: Secreted, signal peptide; EC 3.4.21.39; Secreted; Protease. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: extracellular matrix; extracellular space; extracellular region; intracellular. Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity; peptide binding. Biological Process: interleukin-1 beta biosynthetic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of angiogenesis; cellular protein metabolic process; midbrain development; regulation of inflammatory response; protein processing; angiotensin maturation; proteolysis
size1 :
0.1 mg
price1 :
630 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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