product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse monoclonal antibody to human IL-17A, Clone 7F10
catalog :
MBS592447
quantity :
0.5 mg
price :
490 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[7F10]
reactivity :
human
application :
western blot, enzyme immunoassay
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS592447 image 1
The image below shows that anti-human IL-17A antibody clone 7F10 reacts with human 293 cell expressed human IL-17A antigen (100ng) in Western Blot. The blot was stained with HRP substrate 4-Chloro-1-naphthol
product information
catalog number :
MBS592447
products type :
Antibody
products full name :
Mouse monoclonal antibody to human IL-17A, Clone 7F10
products short name :
[IL-17A]
products name syn :
[mAb anti-Human IL-17A; Mouse monoclonal antibody to human interleukin-17A (IL-17A)]
other names :
[interleukin-17A; Interleukin-17A; interleukin-17A; interleukin 17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8]
products gene name :
[IL-17A]
other gene names :
[IL17A; IL17A; IL17; CTLA8; IL-17; CTLA-8; IL-17A; CTLA8; IL17; IL-17; IL-17A; CTLA-8]
clonality :
Monoclonal
isotype :
IgG2b, Kappa
clone :
[7F10]
host :
Mouse
reactivity :
Human, others not tested
sequence length :
155
specificity :
Reactive with human IL-17A
purity :
Protein G affinity purified
form :
Lyophilized from a solution in 0.01M PBS, pH 7.0
storage stability :
Store at -20°C.
tested application :
Indirect ELISA (EIA), Western Blot (WB)
app notes :
ELISA: The anti-human IL-17A antibody clone 7F10 reacts with human IL-17A in ELISA.
image1 heading :
Western blot
other info1 :
Target Protein: Human IL-17A. Immunogen: Purified recombinant human IL-17A. Reconstitution: Double distilled water is recommended to reconstitute the antibody to 1mg/ml. Research Area: Cytokine. Inflammatory and auto-immune diseases
products categories :
Cytokine; Growth Factor; Inflammatory and Immune Responses
products description :
IL-17A is an inflammatory cytokine produced by Th17 cells, a newly characterised group of CD4 T help cells that plays a role in autoimmune diseases and chronic inflammatory diseases. IL-23 is the main inducer of Th17 cell development. Other cytokines such as TGF-beta, IL-6 and IL-21 were also found to contribute to the procedure. IL-17A belongs to the IL-17 family which includes IL-17A, IL-17B, IL-17C, IL-17D and IL-17E. IL-17, like interferon-gamma, is a potent mediator of delayed-type reaction. IL-17 induces the secretion of many other pro-inflammatory cytokines and chemokines such as IL-6, IL-8, GM-CSF, G-CSF, TGF-beta, TNF-alpha, GRO-alpha, and MCP-1. IL-17 stimulates the expression of NF-kappaB, mitogen activated protein kinase, and prostaglandings by many cell types, and enhances the production of nitric oxide.
ncbi gi num :
4504651
ncbi acc num :
NP_002181.1
ncbi gb acc num :
NM_002190.2
uniprot acc num :
Q16552
ncbi pathways :
Allograft Rejection Pathway (920963); Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Development And Heterogeneity Of The ILC Family Pathway (1458252); IL-17 Signaling Pathway (1474301); IL-17 Signaling Pathway (1473615); IL17 Signaling Pathway (920968); IL23-mediated Signaling Events Pathway (138000); IL27-mediated Signaling Events Pathway (137929)
ncbi summary :
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
uniprot summary :
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
size1 :
0.5 mg
price1 :
490 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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