Mouse monoclonal antibody to human IL-17A | MyBioSource MBS592430 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody to human IL-17A

catalog :

MBS592430

quantity :

0.5 mg

price :

490 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[4C1]

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

The image below shows that anti-human IL-17A antibody 4C1 reacts with human cell expressed human IL-17A antigen (250 ng)in Western blot. The blot was stained with HRP substrate 4-Chloro-4-naphtol.

product information

catalog number :

MBS592430

products type :

Antibody

products full name :

Mouse monoclonal antibody to human IL-17A

products short name :

[IL-17A]

products name syn :

[mAb anti Human IL-17A clone 4C1; Mouse monoclonal antibody to human interleukin-17A (IL-17A)]

other names :

[interleukin-17A; Interleukin-17A; interleukin-17A; interleukin 17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8]

products gene name :

[IL-17A]

other gene names :

[IL17A; IL17A; IL17; CTLA8; IL-17; CTLA-8; IL-17A; CTLA8; IL17; IL-17; IL-17A; CTLA-8]

clonality :

Monoclonal

isotype :

IgG1 Kappa

clone :

[4C1]

host :

Mouse

reactivity :

Human, others no tested.

sequence length :

155

specificity :

Reactive with recombinant human IL-17A

purity :

Protein G affinity purified

form :

Lyophilized from a solution in 0.01M PBS, pH 7.0

storage stability :

Store at -20°C

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Sandwich ELISA: In combination with biotin conjugated anti-human IL-17A clone 3H11 MBS592444, anti- human IL-17A clone 4C1 can be used as capture antibody for quantitative measurement of human IL-17A in sandwich ELISA application.

image1 heading :

Western Blot (WB)

other info1 :

Target Protein: Human IL-17A. Immunogen: Purified, human cell expressed recombinant human IL-17A. Fusion Myeloma: SP2/0. Reconstitution: Double distilled water is recommended to reconstitute the antibody to 1mg/mL.

other info2 :

Research Area: Cytokine. Inflammatory and auto-immune diseases

products categories :

Cytokine; inflammatory and auto-immune responses

products description :

IL-17A is an inflammatory cytokine produced by Th17 cells, a newly characterised group of CD4 T help cells that plays a role in autoimmune diseases and chronic inflammatory diseases. IL-23 is the main inducer of Th17 cell development. Other cytokines such as TGF-beta, IL-6 and IL-21 were also found to contribute to the procedure. IL-17A belongs to the IL-17 family which includes IL-17A, IL-17B, IL-17C, IL-17D and IL-17E. IL-17, like interferon-gamma, is a potent mediator of delayed-type reaction. IL-17 induces the secretion of many other pro-inflammatory cytokines and chemokines such as IL-6, IL-8, GM-CSF, G-CSF, TGF-beta, TNF-alpha, GRO-alpha, and MCP-1. IL-17 stimulates the expression of NF-kappaB, mitogen activated protein kinase, and prostaglandings by many cell types, and enhances the production of nitric oxide.

ncbi gi num :

4504651

ncbi acc num :

NP_002181.1

ncbi gb acc num :

NM_002190.2

uniprot acc num :

Q16552

ncbi pathways :

Allograft Rejection Pathway (920963); Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Development And Heterogeneity Of The ILC Family Pathway (1458252); IL17 Signaling Pathway (920968); IL23-mediated Signaling Events Pathway (138000); IL27-mediated Signaling Events Pathway (137929); Immune System Pathway (1269170); Inflammatory Bowel Disease (IBD) Pathway (842771)

ncbi summary :

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

uniprot summary :

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6p12.2. Cellular Component: extracellular region. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein binding. Biological Process: apoptosis; cell death; cell surface receptor linked signal transduction; cell-cell signaling; immune response; inflammatory response; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter

size1 :

0.5 mg

price1 :

490 USD

more info or order :

MyBioSource product webpage