antibody

Biotin conjugated mAb anti- Amyloid Beta Peptide 42

MBS592380

0.1 mL

475 USD

monoclonal

mouse

biotin

[CA9 10C11]

Antibody

Biotin conjugated mAb anti- Amyloid Beta Peptide 42

[Amyloid Beta Peptide 42]

[Beta amyloid peptide 42 (**Biotin Labeled); Biotin conjugated mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42)]

Monoclonal

IgG2b,k

[CA9 10C11]

Mouse

Human, Other primates, Mouse, Rat. The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is less than 1% in ELISA.

This antibody recognizes the C-terminal sequence (MVGGVVIA) of Abeta42 and full length Abeta42.

Protein G affinity purified

0.01M PBS, pH 7.0 +/- 0.1 in 1% gelatin and 0.1% proclin-300

Store at -20 degree C. Avoid repeated freeze and thaw cycles.

ELISA

Working condition:1:1000-2000

Target Protein: C-terminal of amyloid beta peptide 42. Immunogen: KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Abeta42. Myeloma: Sp2/0-Ag14. Light Chain: Kappa

Research Area: Aging and neurodegenerative diseases. Intended Uses: Tracer**

Tracer antibody in matched antibody pair, biotin conjugated; Matched Antibody Pairs to Human Neurological Disorder Proteins

Description: Biotin conjugated mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42). background: Amyloid beta peptide 42 (Abeta42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Abeta42 and Abeta40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Abeta42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Abeta42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Abeta42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Abeta42 oligomer is the cause of the disease.

0.1 mL

475 USD