antibody

mAb anti-Human Alpha Fetoprotein

MBS592232

0.5 mg

465 USD

monoclonal

mouse

nonconjugated

AFP-Y1

western blot, ELISA, enzyme immunoassay

Antibody

mAb anti-Human Alpha Fetoprotein

Alpha Fetoprotein

Alpha Fetoprotein; Mouse monoclonal antibody to human alpha fetoprotein (AFP)

alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin

AFP; AFP; AFPD; FETA; HPAFP

FETA_HUMAN

Monoclonal

IgG1

AFP-Y1

Mouse

Human. Others not tested. No detectable cross-reaction with human normal serum proteins.

609

React with Alpha Fetoprotein (AFP).

Protein G affinity purified

Lyophilized from a solution in 0.01M PBS, pH7.0

Store at -20 degree C

ELISA (EIA), Western Blot (WB)

ELISA: This antibody can be used as a detection antibody in sandwich immunoassay for human AFP detection in combination with capture antibody mAb AFP-Y1. Western blot: The antibody identifies 68kD AFP on western blot.

Target Protein: Human AFP. Immunogen: Human AFP, which was isolated from amniotic fluid and purified by affinity chromatography. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Research Area: Oncology

Primary antibody-detection antibody in matched antibody pair; Monoclonal Antibodies to Human Tumor Markers

Mouse monoclonal antibody to human AFP, Protein G affinity purified

4501989

NP_001125.1

NM_001134.2

68,678 Da

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; cytoplasm. Molecular Function: metal ion binding. Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle. Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of

0.5 mg

465 USD