antibody

mAb anti-Amyloid Beta Peptide 42

MBS592140

0.5 mg

430 USD

monoclonal

mouse

nonconjugated

CA9 3B3

ELISA, enzyme immunoassay

Antibody

mAb anti-Amyloid Beta Peptide 42

Amyloid Beta Peptide 42

Beta amyloid peptide 42; Mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Abeta42)

Monoclonal

IgG2b,k

CA9 3B3

Mouse

Human, Other primates, Mouse, Rat. The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is about 5% in ELISA.

This antibody recognizes the C-terminal sequence (MVGGVVIA) of Abeta42 and full length Abeta42. Beta amyloid peptide 42

Protein G affinity purified

Lyophilized from a solution in 0.01M PBS, pH 7.2

Store at -20 degree C

ELISA (EIA)

ELISA: In combination with capturer anti-amyloid peptide N-terminal antibody (mAb clone NT 4A2), the antibody can detect Abeta42 in Sandwich ELISA assay. Immuno-blot: Detect Abeta42 on dot blot using anti- Abeta42 clone CA9 3B3 (1mug/mL) on 10ng /dot of Abeta40 or Abeta42.

Target Protein: C-terminal of amyloid beta peptide 42. Immunogen: KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Abeta42. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Research Area: Aging and neurodegenerative diseases

Primary antibody; Monoclonal Antibodies to Neurological Disorder Proteins

Amyloid beta peptide 42 (A~42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. A~42 and A~40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. A~42 (42 amino acids) is very fibrillogenic. The beta pleated structure of A~42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that A~42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of A~42 oligomer is the cause of the disease.

0.5 mg

430 USD