mAb anti-Human Beta 2 Microglobulin | MyBioSource MBS592049 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

mAb anti-Human Beta 2 Microglobulin

catalog :

MBS592049

quantity :

0.5 mg

price :

445 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[D2A10]

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Detect 100 ng recombinant human B2MG antigen (right lane) using anti-human B2MG mAb D2A10 at 1 ug/mL dilution

image 2 :

Stainning of methanol-fixed Hela cells: Mouse anti-Human beta 2 Microglobulin monoclonal antibody (D2A10) 1:50 (20ug/mL).

image 3 :

Is the histogram of Mouse anti-Human beta 2 Micro Globulin monoclonal antibody 1:100 (10ug/mL) staining of Hela cells. Black line histogram represents the isotype control, Mouse anti-TB 38Kd antigen monoclonal antibody (MBS592053, B12F8).

product information

catalog number :

MBS592049

products type :

Antibody

products full name :

mAb anti-Human Beta 2 Microglobulin

products short name :

[Beta 2 Microglobulin]

products name syn :

[Beta 2 Microglobulin; Mouse monoclonal antibody to human beta 2 microglobulin (B2MG)]

other names :

[beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin]

other gene names :

[B2M; B2M]

uniprot entry name :

B2MG_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

[D2A10]

host :

Mouse

reactivity :

Human. Others not tested

sequence length :

119

specificity :

Beta 2 Microglobulin

purity :

Protein G affinity purified

form :

Lyophilized from a solution in 0.01M PBS, pH 7.2

storage stability :

Store at -20°C

tested application :

ELISA (EIA)

app notes :

ELISA: The antibody reacts with human B2MG.

image1 heading :

Western Blot

image2 heading :

Immunofluorescent

image3 heading :

Flow Cytometry

other info1 :

Target Protein: Human beta 2 microglobulin (B2MG) . Immunogen: Highly purified beta 2 microglobulin from human urine. Fusion Myeloma: Sp2/0-Ag14 . Light Chain: Kappa . Reconstitution: Double distilled water is recommended to reconstitute the antibody.

other info2 :

Research Area: Renal disease, plasma cell cancer

products categories :

Primary antibody; Monoclonal Antibodies to Human Inflammatory Proteins

products description :

Human beta 2 microglobulin (B2MG) is a component of major histocompatibility complex 1 (MHC1). It is abundant at the surface of lymphocytes and exists at the surface of all cell types except red cells and platelets. B2MG is normally filtered out of blood through glomeruli, but the process is impaired in patients with renal diseases. Elevated B2MG level is implicated with lymphoma, multiple myeloma, renal diseases, viral infections and auto-immune conditions.

ncbi gi num :

4757826

ncbi acc num :

NP_004039.1

ncbi gb acc num :

NM_004048.2

ncbi pathways :

Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)

ncbi summary :

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

uniprot summary :

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic

size1 :

0.5 mg

price1 :

445 USD

more info or order :

MyBioSource product webpage