mAb anti-Human Beta 2 Microglobulin | MyBioSource MBS592016 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

mAb anti-Human Beta 2 Microglobulin

catalog :

MBS592016

quantity :

0.5 mg

price :

430 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D3A2

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS592016

products type :

Antibody

products full name :

mAb anti-Human Beta 2 Microglobulin

products short name :

Beta 2 Microglobulin

products name syn :

Beta 2 Microglobulin; Mouse monoclonal antibody to human beta 2 microglobulin (B2MG)

other names :

beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin

other gene names :

B2M; B2M

uniprot entry name :

B2MG_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

D3A2

host :

Mouse

reactivity :

Human. Others not tested

sequence length :

119

specificity :

Beta 2 Microglobulin

purity :

Protein G affinity purified

form :

Lyophilized from a solution in 0.01M PBS, pH 7.2

storage stability :

Store at -20 degree C

tested application :

ELISA (EIA)

app notes :

ELISA: The antibody can detect human B2MG in Sandwich ELISA in combination with capture antibody, anti-B2MG mAb D2E9.

other info1 :

Target Protein: Human beta 2 microglobulin. Immunogen: Recombinant human beta 2 microglobulin. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

other info2 :

Research Area: Renal disease, plasma cell cancer

products categories :

Primary antibody-Detection antibody in matched antibody pair; Monoclonal Antibodies to Human Inflammatory Proteins

products description :

Mouse monoclonal antibody to Human Beta 2 MG, Protein G affinity purified. Human beta 2 microglobulin (B2MG) is a component of major histocompatibility complex 1 (MHC1). It is abundant at the surface of lymphocytes and exists at the surface of all cell types except red cells. B2MG is normally filtered out of blood through glomeruli, but the process is impaired in patients with renal diseases. Elevated B2MG levels are implicated with lymphoma, multiple myeloma, renal diseases, viral infections and autoimmune conditions.

ncbi gi num :

4757826

ncbi acc num :

NP_004039.1

ncbi gb acc num :

NM_004048.2

ncbi mol weight :

13,715 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)

ncbi summary :

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

uniprot summary :

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; endoplasmic reticulum lumen; early endosome membrane; cytoplasm; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic

size1 :

0.5 mg

price1 :

430 USD

more info or order :

MyBioSource product webpage