mAb anti-human GM-CSF | MyBioSource MBS592011 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

mAb anti-human GM-CSF

catalog :

MBS592011

quantity :

0.5 mg

price :

465 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S333

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS592011

products type :

Antibody

products full name :

mAb anti-human GM-CSF

products short name :

GM-CSF

products name syn :

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF); Mouse monoclonal antibody to human granulocyte macrophage colony stimulating factor (GM-CSF)

other names :

GM-CSF; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; CSF; granulocyte macrophage-colony stimulating factor; molgramostin; sargramostim; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Molgramostin; Sargramostim

products gene name :

GM-CSF

other gene names :

CSF2; CSF2; GMCSF

uniprot entry name :

CSF2_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

S333

host :

Mouse

reactivity :

Human. Other species not tested. Does not show any cross reaction with other human cytokines or growth factors tested such as M-CSF, G-CSFR, IL-8, IL-16, IL-1beta, TGF-beta1 and TNF-alpha.

sequence length :

144

specificity :

Reacts with natural and recombinant human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF)

purity :

Protein G affinity purified

form :

Lyophilized from a solution in 0.01M PBS, pH 7.2.

storage stability :

Store at -20 degree C

tested application :

ELISA (EIA)

other info1 :

Target Protein: Human GM-CSF. Immunogen: Purified recombinant human GM-CSF. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distillated water is recommended to reconstitute the antibody.

other info2 :

Research Area: Hematopoiesis, infection

products categories :

Primary antibodies; Monoclonal Antibodies to Human Cytokines and Growth Factors

products description :

Mouse monoclonal antibody to human granulocyte macrophage colony stimulating factor (GMCSF), Protein G affinity purified. GM-CSF is an extracellular homodimer polyprotein, functioning as a hematopoietic growth factor and immune modulator. It can be produced and act upon a variety of cell types, including T-lymphocytes, Blymphocytes, monocytes/macrophages, endothelial cells, fibroblasts, stromal cells, mesothelial cells, keratinocytes, osteoblasts, uterine epithelial cells, synoviocytes, mast cells and various solid tumors. GM-CSF stimulates stem cells to produce granulocytes and monocytes to cope with infection. Recombinant GM-CSF has been applied to boost white blood cell in cancer patients after chemotherapy and may also be useful as an immune tonic for anemia and AIDS patients.

ncbi gi num :

183364

ncbi acc num :

AAA52578.1

ncbi mol weight :

16,295 Da

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493)

ncbi summary :

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

uniprot summary :

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Protein type: Cytokine; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity. Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication

size1 :

0.5 mg

price1 :

465 USD

more info or order :

MyBioSource product webpage