antibody

mAb anti-Human IL-1beta

MBS592009

0.5 mg

465 USD

monoclonal

mouse

nonconjugated

464

ELISA, enzyme immunoassay

Antibody

mAb anti-Human IL-1beta

IL-1beta

Interleukin-1 Beta (IL-1beta); Interleukin-1 Beta (IL-1b); Mouse monoclonal antibody to human Interleukin-1 beta (IL-1beta)

interleukin-1 beta proprotein; Interleukin-1 beta; interleukin-1 beta; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; interleukin 1, beta; Catabolin

IL-1beta

IL1B; IL1B; IL-1; IL1F2; IL1-BETA

IL1B_HUMAN

Monoclonal

IgM,k

464

Mouse

Human. Other species not tested. Does not show any cross reaction with recombinant human IL-1alpha, recombinant murine IL-1alpha or IL-1beta.

269

Reactive with natural and recombinant human Interleukin-1 Beta (IL-1beta)

Protein G affinity purified

Lyophilized from a solution in 0.01M PBS, pH 7.2.

Store at -20 degree C

ELISA (EIA)

ELISA: React with IL-1beta

Target Protein: Human IL-1beta. Immunogen: Purified recombinant human IL-1beta. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distillated water is recommended to reconstitute the antibody.

Research Area: Cytokine, Inflammation

Primary antibodies; Monoclonal Antibodies to Human Cytokines and Growth Factors

Interleukin 1 Beta (IL-1Beta) shares the IL-1 receptor with other cytokines in IL-1 family. It is primarily produced by activated macrophage as a proprotein, which is cleaved by caspase 1 to become active. Like IL-1 Alpha, IL-1Beta is an important mediator of innate immunity. IL-1Beta stimulates lymphocyte proliferation and the production of TNF-Alpha, IL-6 and IL-8. IL-1Beta and TNF-Alpha can synergically act at NGkB and mitogen kinases including JNKs and p38 MARKs, thus leading to the selective expression of genes for immunity and inflammation.

10835145

NP_000567.1

NM_000576.2

30,748 Da

African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Apoptosis Pathway (83060); Apoptosis Pathway (470); Cellular Roles Of Anthrax Toxin Pathway (138076)

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 2q14. Cellular Component: extracellular space; extracellular region; cytosol; secretory granule. Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity. Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of MAP kinase activity; positive regulation of nitric oxide biosynthetic process; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of NF-kappaB import into nucleus; positive regulation of lipid catabolic process; fever; positive regulation of membrane protein ectodomain proteolysis; response to carbohydrate stimulus; activation of NF-kappaB transcription factor; cell-cell signaling; positive regulation of phagocytosis; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of heterotypic cell-cell adhesion; positive regulation of mitosis; smooth muscle adaptation; interleukin-1 beta production; positive regulation of interleukin-6 production; positive regulation of angiogenesis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of lipid metabolic process; sequestering of triacylglycerol; positive regulation of histone phosphorylation; apoptosis; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of protein export from nucleus; negative regulation of cell proliferation; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; response to ATP; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of fever; positive regulation of histone acetylation; immune response; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion; embryo implantation. Disease: Gastric Cancer, Hereditary Diffuse

0.5 mg

465 USD