Mouse Anti-Human IL-2 Monoclonal Antibody Datasheet | MyBioSource MBS592008 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti-Human IL-2 Monoclonal Antibody Datasheet

catalog :

MBS592008

quantity :

0.5 mg

price :

465 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6B1

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS592008

products type :

Antibody

products full name :

Mouse Anti-Human IL-2 Monoclonal Antibody Datasheet

products short name :

IL-2

products name syn :

Interleukin-2 (IL-2); Mouse monoclonal antibody to human Interleikin-2 (IL-2)

other names :

IL-2, partial; IL-2 protein; IL-2 protein

products gene name :

IL-2

other gene names :

IL-2

uniprot entry name :

O95974_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

clone :

6B1

host :

Mouse

reactivity :

Human. Other species not tested. Cross-reactivity was not identified.

sequence length :

specificity :

Reactive to recombinant human Interleukin-2 (IL-2)

purity :

Protein G affinity purified

form :

Lyophilized from a solution in 0.01M PBS, pH 7.2.

storage stability :

Store at -20 degree C

tested application :

ELISA (EIA)

app notes :

ELISA: Anti-human IL-2 mAb clone 6B1 can match with clone 9F9 in sandwich ELISA to detect the recombinant human IL-2 antigen.

other info1 :

Target Protein: Human IL-2. Immunogen: Recombinant human IL-2. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00 mg/mL. Product Type: Primary antibody

other info2 :

Research Area: Cytokine, adapted immunity

products categories :

Primary antibodies; Monoclonal Antibodies to Human Cytokines and Growth Factors

products description :

Mouse monoclonal antibody to human Interleikin-2 (IL-2). Background: Interleukin 2 (IL-2) is the cytokine secreted by T-cells immediately after the T cell receptors are activated by the binding of foreign antigens. The cytokine stimulates the growth, proliferation and differentiation of naïve T-cells into “effecter T-cells”, promotes the survival of antigen specific “memory T-cell”, and stimulates the maturation of “regulatory T-cells”. The cytokine is crucial for the development of adapted immunity, immune memory and the modulation of auto-immunity.

ncbi gi num :

4029234

ncbi acc num :

CAA07317.1

ncbi mol weight :

15.5kDa

ncbi summary :

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

uniprot summary :

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Protein type: Secreted; Secreted, signal peptide; Oncoprotein; Cytokine. Chromosomal Location of Human Ortholog: 4q26-q27. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; kinase activator activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding. Biological Process: positive regulation of isotype switching to IgG isotypes; negative regulation of heart contraction; natural killer cell activation; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; cell-cell signaling; protein kinase C activation; positive regulation of cell proliferation; positive regulation of B cell proliferation; cell adhesion; T cell differentiation; positive regulation of interleukin-17 production; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of cell growth; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of B cell apoptosis; positive regulation of inflammatory response; negative regulation of apoptosis

size1 :

0.5 mg

price1 :

465 USD

more info or order :

MyBioSource product webpage