antibody

mAb anti-Human Alpha Fetoprotein

MBS592005

0.5 mg

465 USD

monoclonal

mouse

nonconjugated

AFP-Y2

Antibody

mAb anti-Human Alpha Fetoprotein

Alpha Fetoprotein

Alpha Fetoprotein (AFP); Mouse monoclonal antibody to human alpha fetoprotein (AFP)

alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin

AFP; AFP; AFPD; FETA; HPAFP

FETA_HUMAN

Monoclonal

IgG2b

AFP-Y2

Mouse

Human. Others not tested. No detectable cross-reaction with human normal serum proteins.

609

React with Alpha Fetoprotein (AFP).

Protein G affinity purified

Lyophilized from a solution in 0.01M PBS, pH7.0

Store at -20 degree C

ELISA: This antibody can be used as a capture antibody in sandwich immunoassay for human AFP detection in combination with HRP conjugate derived from detection antibody AFP-Y2. Western blot: The antibody identifies 68kD AFP on western blot.

Target Protein: Human AFP. Immunogen: Human AFP, which was isolated from amniotic fluid and purified by affinity chromatography. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Research Area: Oncology . Intended Uses: Capture

Primary antibody-Capture antibody in matched antibody pair; Matched Antibody Pairs to Human Tumor Markers Proteins

Alpha fetoprotein (AFP) is a 70kD glycoprotein which is produced primarily by liver cells in fetuses. It exists in significant amount in foetal plasma and decrease rapidly after birth. Moderate amount of AFP exists in serum of pregnant women. Monitoring mother’s serum AFP level in second trimester pregnancy can help assessing birth defects such as Down syndrome, neural tube defect and anencephaly. Elevated AFP level in men, children and non-pregnant women is associated with neoplastic conditions in lever, testicle or ovary.

4501989

NP_001125.1

NM_001134.2

68,678 Da

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; cytoplasm. Molecular Function: metal ion binding. Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle. Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of

0.5 mg

465 USD