antibody

Epidermal Growth Factor (EGF) Chicken Polyclonal Antibody

MBS588214

0.1 mg

625 USD

polyclonal

chicken

nonconjugated

Antibody

Epidermal Growth Factor (EGF) Chicken Polyclonal Antibody

[Epidermal Growth Factor (EGF)]

[epidermal growth factor (beta-urogastrone); Pro-epidermal growth factor; pro-epidermal growth factor; epidermal growth factor; Epidermal growth factorAlternative name(s):Urogastrone]

[EGF]

[EGF; EGF; URG; HOMG4; EGF]

Polyclonal

Chicken

1207

Lyophilized purified total IgY in PBS pH7.4

Lyophilized antibody can be kept at 4 degree C for up to 3 months and should be kept at-20 degree C for long-term storage. To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20 degree C) or for long-term storage (-80 degree C). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Immunohistochemistry (IHC)

Preservative: Ampicillin and streptomycin, 0.05% sodium aside.

119626662

EAX06257.1

129,256 Da

Adaptive Immune System Pathway (366160); Arf6 Signaling Events Pathway (138034); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Ceramide Signaling Pathway (138023); Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Constitutive Signaling By Aberrant PI3K In Cancer Pathway (685535); Constitutive Signaling By EGFRvIII Pathway (1127578); Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway (530769)

This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

0.1 mg

625 USD