MyBioSource

protein

LBP, Human, Peptide

MBS584636

0.5 mg

775 USD

MBS584636

Protein

LBP, Human, Peptide

LBP

Lipopolysaccharide-binding protein; Lipopolysaccharide-binding protein; lipopolysaccharide-binding protein; LPS-binding protein; BPI fold containing family D, member 2; lipopolysaccharide binding protein; N/A

LBP

LBP; LBP; BPIFD2; LBP

LBP_HUMAN

Human

481

>95%

Lyophilized, purified LBP-peptide from human LBP protein in PBS. The exact peptide amount is indicated on the label. Reconstitute the vial by pipetting sterile, endotoxin free phosphate buffered saline.

Lyophilized product should be stored at 4 degree C. The stock solution should be stored in aliquots at -70 degree C in polypropylene tubes. LBP-peptide stock solution should never be thawed more than once. Repeated freeze and thaw cycles will cause loss of LBP-peptide activity. Under recommended storage conditions, product is stable for more than one year.

Application Use: For neutralization of biological activity dilutions have to be made according to the amounts protein to be inactivated. Further dilutions should be made by using protein stabilized phosphate buffered saline, pH 7. (Never use fresh serum/plasma). Be aware: endotoxin will bind LBP-peptide.

Product Description: LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into lipoproteins which neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria. The LBP-peptide, amino acids 86-99, binds lipid A and neutralizes LPS in vivo and in vitro.

Bucki, R et al; Extracellular Gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. J of Immunol. 2008, 181: 4936

116242615

P18428.3

53,384 Da

IL6-mediated Signaling Events Pathway 137932!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!NF-kappa B Signaling Pathway 634527!!Regulation Of Toll-like Receptor Signaling Pathway 920955!!Salmonella Infection Pathway 375172!!Salmonella Infection Pathway 375149!!Toll Like Receptor 4 (TLR4) Cascade Pathway 106398!!Toll-Like Receptors Cascades Pathway 106388!!Toll-like Receptor Signaling Pathway 83076

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

0.5 mg

775 USD