product summary
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company name :
MyBioSource
product type :
antibody
product name :
C3c, Human, mAb 4
catalog :
MBS584395
quantity :
0.1 mg
price :
555 USD
clonality :
monoclonal
host :
human
conjugate :
nonconjugated
application :
immunoprecipitation
more info or order :
product information
catalog number :
MBS584395
products type :
Antibody
products full name :
C3c, Human, mAb 4
products short name :
C3c
products gene name :
C3c
clonality :
Monoclonal
isotype :
IgG2a. Species: Rat
host :
Human
form :
1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
storage stability :
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
tested application :
Immunoprecipitation (IP)
app notes :
The monoclonal antibody 4 can be used for immunoprecipitation.
products description :
Product Description: The monoclonal antibody 4 recognizes the cleaved human C3 fragment C3c. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. The monoclonal antibody 4 recognizes a conformational epitope in C3c, C3b and iC3b.
products references :
1. Lachmann, P et al; Three monoclonal antibodies to human C3. Immunology 1980, 41: 503 2. Lachmann, P et al; Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies. J Exp Med 1982, 156: 205 . 3. Lachmann, P et al; Use of monoclonal anti-C3 antibodies to characterise the fragments of C3 that are found on erythrocytes. Vox Sang 1983, 45: 367
size1 :
0.1 mg
price1 :
555 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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