SAA-1, Human, mAb Reu86.1 | MyBioSource MBS584228 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SAA-1, Human, mAb Reu86.1

catalog :

MBS584228

quantity :

0.1 mg

price :

580 USD

clonality :

monoclonal

host :

human

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, flow cytometry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS584228

products type :

Antibody

products full name :

SAA-1, Human, mAb Reu86.1

products short name :

SAA-1

other names :

serum amyloid A-1 protein; Serum amyloid A-1 protein; serum amyloid A-1 protein; serum amyloid A 2; serum amyloid A 1

products gene name :

SAA-1

other gene names :

Saa1; Saa1; Saa2; Saa-1

uniprot entry name :

SAA1_MOUSE

clonality :

Monoclonal

isotype :

IgG1

host :

Human

reactivity :

Mouse

sequence length :

122

form :

1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.

storage stability :

Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.

tested application :

F, Immunoasssay (IA), P, Western Blot

app notes :

Application Use: The antibody can be used for western blotting, immuno assays as detection and immunohistology on frozen and praffin sections.

products description :

Product Description: The serum amyloid A (SAA) family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma, and constitutive SAAs (C-SAAs). Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000-fold during inflammation. Several studies have stressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumor tissues. SAA has been found to have binding sites for high density lipoproteins, calcium, laminin, and heparin/heparan-sulfate. Also adhesion motifs were identified and new functions, affecting cell adhesion, migration, proliferation and aggregation discovered. These findings emphasize the importance of SAA in various physiological and pathological processes, including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia. SAA has also a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high-density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease processes. In addition, recent experiments suggest that SAA may play a "housekeeping" role in normal human tissues. Elevated levels of SAA over time predispose to secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissue and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis. The antibody is raised against human SAA and Helix Pomatia Haemocyanine. It reacts specifically with SAA-1, the major isoform of SAA in plasma.

products references :

1. Hazenberg, B et al; Immunohistochemical detection of Amyloid AA in formaline-fixed paraffin-embedded rectal biopsies with the monoclonal antibody anti-human SAA antibody Reu.86.2. Amyloid and Amyloidosis 1990, VIth International Symposium on Amyloidosis: 809. 2. Hazenberg, B et al; Monoclonal antibody based ELISA for human SAA. Amyloid and Amyloidosis, eds. LB Natvig et al, Kluwer Acad Publ 1990: 898. 3. Wilkins, J et al; Rapid automated enzyme immunoassays of Serum Amyloid A. Clin Chem 1994, 40: 1284. 4. Hazenberg, B et al; A quantitative method for detecting deposits of amyloid A protein in aspirated fat tissue of patients with arthritis. Ann Rheum Dis 1999, 58: 96

ncbi gi num :

6677843

ncbi acc num :

NP_033143.1

ncbi gb acc num :

NM_009117.3

ncbi mol weight :

13,770 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (970703); Advanced Glycosylation Endproduct Receptor Signaling Pathway (1001253); Amyloids Pathway (1000612); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1000591); Class A/1 (Rhodopsin-like Receptors) Pathway (1000942); Cytosolic Sensors Of Pathogen-associated DNA Pathway (1001263); DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway (1001271); Disease Pathway (970606); Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway (1000948); G Alpha (i) Signalling Events Pathway (1000973)

uniprot summary :

SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space; extracellular region. Molecular Function: heparin binding; protein binding; G-protein-coupled receptor binding; chemoattractant activity. Biological Process: cholesterol metabolic process; acute-phase response

size1 :

0.1 mg

price1 :

580 USD

more info or order :

MyBioSource product webpage