product summary
Loading...
company name :
MyBioSource
product type :
ELISA/assay
product name :
Thyroid Peroxidase (TPQ) IgG ELISA Kit
catalog :
MBS580088
quantity :
96-Strip-Wells
price :
235 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS580088
products type :
ELISA Kit
products full name :
Thyroid Peroxidase (TPQ) IgG ELISA Kit
products short name :
Thyroid Peroxidase IgG
products name syn :
Thyroid Peroxidase (TPO) IgG ELISA
other names :
thyroid peroxidase, partial; Thyroid peroxidase; thyroid peroxidase; thyroid microsomal antigen; thyroperoxidase; thyroid peroxidase
products gene name :
TPQ
other gene names :
TPO; TPO; MSA; TPX; TDH2A; TPO
uniprot entry name :
PERT_HUMAN
reactivity :
Human
sequence length :
38
storage stability :
Product should be stored at 2-8 degree C. Product is stable for 24 months from the date of manufacturing.
other info1 :
Samples: Human serum or plasma
other info2 :
Intended Uses: The Thyroid Peroxidase (TPO) IgG ELISA Kit is intended for the detection of IgG antibody to Thyroid Peroxidase in human serum or plasma. For research use only.
products categories :
Autoimmune Disorders
ncbi gi num :
4261820
ncbi acc num :
AAD14120.1
uniprot acc num :
P07202
ncbi mol weight :
92,063 Da
ncbi pathways :
Amine-derived Hormones Pathway (160983); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Thyroid Hormone Biosynthesis, Tyrosine = Triiodothyronine/thyroxine Pathway (413358); Thyroid Hormone Biosynthesis, Tyrosine = Triiodothyronine/thyroxine Pathway (468236); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)
ncbi summary :
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
uniprot summary :
TPO: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). An alternative splicing in the thyroperoxidase mRNA can cause Graves disease. Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A). A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Belongs to the peroxidase family. XPO subfamily. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; EC 1.11.1.8; Amino Acid Metabolism - tyrosine; Oxidoreductase; Mitochondrial. Chromosomal Location of Human Ortholog: 2p25. Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; plasma membrane. Molecular Function: peroxidase activity; heme binding; iodide peroxidase activity; calcium ion binding. Biological Process: embryonic hemopoiesis; hydrogen peroxide catabolic process; thyroid hormone generation; response to oxidative stress; hormone biosynthetic process. Disease: Thyroid Dyshormonogenesis 2a
size1 :
96-Strip-Wells
price1 :
235 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!