Beta2 Microglobulin ELISA Kit | MyBioSource MBS580042 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Beta2 Microglobulin ELISA Kit

catalog :

MBS580042

quantity :

96-Strip-Wells

price :

295 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS580042

products type :

ELISA Kit

products full name :

Beta2 Microglobulin ELISA Kit

products short name :

Beta2 Microglobulin

products name syn :

Beta 2 Microglobulin ELISA

other names :

beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin

other gene names :

B2M; B2M

uniprot entry name :

B2MG_HUMAN

reactivity :

Human

sequence length :

119

storage stability :

Product should be stored at 2-8 degree C. Product is stable for 24 months from the date of manufacturing.

other info1 :

Samples: Human serum

other info2 :

Intended Uses: The Beta 2 Microglobulin ELISA Kit is intended for the quantitative determination of Beta-2 Microglobulin (B2MG) Concentration in Human Serum. For research use only.

products categories :

Cancer Markers

products references :

1. Berggard I and Beam AG. 1968. Isolation and properties of a low molecular weight beta-2 globulin occurring in human biological fluids. J Biol Chem 243: 4095-4103. 2. Grey HM, Kubo RT, Colon SM, Poulik MD, Cresswell P, Springer T, Turner M and Stronminger JL. 1973. The small subunit of HL-A antigens is beta2-microglobulin. J Exp Med 138: 1608-1612. 3. Nakamuro K, Tanigaki N and Pressman D., 1973. Multiple common properties of human B2-microglobulin and the common portion fragment derived from HL-A antigen molecules. Proc Natl Acad Sci 70: 2863-2865. 4. Evrin PE and Wibell L., 1972. The serum levels and urinary excretion of beta2-microglobulin in apparently healthy subjects. Scand J Clin Lab Invest 29:69-74. 5. Crisp AJ, Coughlan RJ, Mackintosh D, Clark B, and Panayi GS. 1983. beta2-microglobulin plasma levels reflect disease activity in rheumatoid arthritis. J Rheumatol 10: 954-956.

ncbi gi num :

179318

ncbi acc num :

AAA51811.1

uniprot acc num :

P61769

ncbi mol weight :

13,715 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)

ncbi summary :

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

uniprot summary :

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic

size1 :

96-Strip-Wells

price1 :

295 USD

more info or order :

MyBioSource product webpage