product summary
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company name :
MyBioSource
product type :
other
product name :
AZD9291
catalog :
MBS576635
quantity :
5 mg
price :
135 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS576635
products type :
Inhibitor
products full name :
AZD9291
products short name :
[AZD9291]
products gene name :
[AZD9291]
storage stability :
2 years -80°C in solvent. 3 years -20°C in powder
app notes :
Cell Assay: AZD-9291 is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. PC-9 cells are seeded into T75 flasks (5×105 cells/flask) in RPMI growth media and incubated at 37°C, 5% CO2. The following day the media is replaced with media supplemented with a concentration of EGFR inhibitor equal to the EC50 concentration predetermined in PC-9 cells. Media changes are carried out every 2-3 days and resistant clones allowed to grow to 80% confluency prior to the cells being trypsinised and reseeded at the original seeding density in media containing twice the concentration of EGFR inhibitor. Dose escalations are continued until a final concentration of 1.5 uM Gefitinib, 1.5 uM Afatinib, 1.5 uM WZ4002 or 160 nM AZD-9291 are achieved[1]. Reference:. 1. Patent. 2013, WO2013014448 A1. 2. Cross, et al. Mol Cancer Ther. 2013, 12, A109.
other info1 :
CAS Number: 1421373-65-0. Molecular Formula: C28H33N7O2. Solubility: DMSO: 92 mg/mL (184.1 mM). Ethanol: 22 mg/mL (44 mM). Water: < 1 mg/mL. Receptor (IC50): EGFR (Exon 19 deletion): 12.92nM. EGFR (L858R/T790M): 1nM. Animal Experiment: Animal Model: Mice
products description :
Osimertinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC).
ncbi mol weight :
499.61
size1 :
5 mg
price1 :
135 USD
size2 :
1ml/10mM (in DMSO)
price2 :
135
size3 :
10 mg
price3 :
150
size4 :
100 mg
price4 :
185
size5 :
200 mg
price5 :
205
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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