product summary
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company name :
MyBioSource
product type :
other
product name :
IOX 2
catalog :
MBS575732
quantity :
2 mg
price :
135 USD
more info or order :
MyBioSource product webpage
image
image 1 :
MyBioSource MBS575732 image 1
product information
catalog number :
MBS575732
products type :
Inhibitor
products full name :
IOX 2
products short name :
[IOX 2]
products gene name :
[IOX 2]
sequence length :
6
storage stability :
2 years-80°C in solvent. 3 years -20°C powder.
image1 heading :
Structure
other info1 :
CAS: 931398-72-0. Formula: C19H16N2O5. Solubility: DMSO: 7 mg/ml (18.96 mM). Ethanol: 3)[1].
other info2 :
Cell Assay: IOX2 is prepared in DMSO and stored, and then diluted with appropriate medium before use[I]. Both VHL-defective (renal carcinoma cells with an empty vector, RC(4) and VHL-competent cells human embryonic kidney HEK293T, osteosarcoma U20S and RCC4jVHLHA (RCC4 stably transfected with C-terminal HA-tagged wt VHL) are used. Cells are treated with DMSO (control) and tested compounds (e.g., IOX2) (dissolved in DMSO except for DMOG which is dissolved in PBS and added directly to culture medium) for 4-5 h. Cell extracts are probed with antibodies to hydroxyPro564 (CODD-OH) and hydroxy-Asn803 (CAD-OH). HIF-1alpha band intensities are used to normalize hydroxylation signals [1]. Animal Experimental: Zebrafish
products description :
IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
ncbi mol weight :
352.34
size1 :
2 mg
price1 :
135 USD
size2 :
5 mg
price2 :
155
size3 :
1ml/10mM (in DMSO)
price3 :
155
size4 :
10 mg
price4 :
170
size5 :
25 mg
price5 :
275
size6 :
50 mg
price6 :
435
size7 :
100 mg
price7 :
720
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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