Rabbit anti Human Butyrylcholinesterase | MyBioSource MBS573138 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Human Butyrylcholinesterase

catalog :

MBS573138

quantity :

10 mg

price :

250 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS573138

products type :

Antibody

products full name :

Rabbit anti Human Butyrylcholinesterase

products short name :

Butyrylcholinesterase

other names :

butyrylcholinesterase; Cholinesterase; cholinesterase; cholinesterase 1; choline esterase II; pseudocholinesterase; butyrylcholine esterase; cholinesterase (serum) 2; acylcholine acylhydrolase; butyrylcholinesterase; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase

other gene names :

BCHE; BCHE; E1; CHE1; CHE2; CHE1

uniprot entry name :

CHLE_HUMAN

clonality :

Polyclonal

host :

Rabbit. Source: . Butyrylcholinesterase isolated and purified from human serum. Freund's complete adjuvant is used in the first step of the immunization procedure.

reactivity :

Human

specificity :

IgG fraction of polyclonal Rabbit antiSerum to butyrylcholinesterase from Human Serum.

storage stability :

The lyophilised IgG fraction is shipped at ambient temperature and may be stored at =4 Deg. C;

tested application :

Indirect Immunofluorescence (IF), ELISA (EIA), Dot Blot (DB), Immunoblotting (IB)

app notes :

Indirect immunofluorescence, ELISA, Dot blot, immunoblotting. Working dilutions in non-precipitating antibody-binding techniques may vary widely, but may be between 1/1,000 and 1/40,000

products categories :

Secondary Antibody

products description :

The reagents were evaluated for potency, purity and specificity using most or all of the following techniques: immunoelectrophoresis, cross-immunoelectrophoresis, single radial immunodiffusion (Ouchterlony), block titration, ELISA, immunoblotting and enzyme inhibition. This product is intended for use in precipitating and non-precipitating antibody-binding assays (such as e.g., ELISA and Western blotting and immunofluorescence or histochemical techniques); to prepare an insoluble immune-affinity adsorbent; for labeling with a marker of the customer’s own choice. Product: . Purified hyperimmune rabbit IgG lyophilised from a solution in phosphate buffered saline (PBS, pH7.2). No preserved added, as it may interfere with the antibody activity. No foreign protein added.

ncbi gi num :

1311630

ncbi acc num :

AAA99296.1

uniprot acc num :

P06276

ncbi mol weight :

68,418 Da

ncbi pathways :

Irinotecan Pathway (198905); Metabolism Of Proteins Pathway (106230); Peptide Hormone Metabolism Pathway (771603); Synthesis, Secretion, And Deacylation Of Ghrelin Pathway (119538)

ncbi summary :

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

uniprot summary :

BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family. Protein type: Hydrolase; Nuclear envelope; Secreted, signal peptide; EC 3.1.1.8; Secreted. Chromosomal Location of Human Ortholog: 3q26.1-q26.2. Cellular Component: membrane; nuclear envelope lumen; endoplasmic reticulum lumen; extracellular region. Molecular Function: identical protein binding; choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity. Biological Process: response to drug; response to alkaloid; negative regulation of cell proliferation; choline metabolic process; cellular protein metabolic process; cocaine metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission

size1 :

10 mg

price1 :

250 USD

more info or order :

MyBioSource product webpage