other

Haptoglobin Antigen >=95%

MBS568603

2 mg

365 USD

Antigen

Haptoglobin Antigen >=95%

[Haptoglobin]

[haptoglobin; Haptoglobin; haptoglobin; haptoglobin; Zonulin]

[HP; HP; BP; HPA1S; HP2ALPHA2]

HPT_HUMAN

Human Plasma

406

>=95% by SDS-PAGE

Lyophilized, salt free

Store at <=-20°C

Immunogen Grade

Testing: Shown to be non reactive for HBsAg, anti-HCV, anti-HCV, anti-HBc, and negative for anti-HIV 1&2 by FDA approved tests.

Serum Proteins

386783

AAA88080.1

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Scavenging Of Heme From Plasma Pathway (1269898); Vesicle-mediated Transport Pathway (1269876); Amb2 Integrin Signaling Pathway (137945)

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular region; extracellular space. Molecular Function: antioxidant activity; hemoglobin binding; protein binding; serine-type endopeptidase activity. Biological Process: acute-phase response; defense response; defense response to bacterium; immune system process; negative regulation of oxidoreductase activity; proteolysis; receptor-mediated endocytosis; response to hydrogen peroxide. Disease: Anhaptoglobinemia

2 mg

365 USD