antibody

Calcitonin gene related peptide polyclonal antibody

MBS565286

0.025 mL

200 USD

polyclonal

sheep

nonconjugated

Antibody

Calcitonin gene related peptide polyclonal antibody

[Calcitonin gene related peptide]

[CGRP]

[Calcitonin gene-related peptide 1; Calcitonin gene-related peptide 1; calcitonin gene-related peptide 1; calcitonin-related polypeptide alpha; Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I]

[CGRP]

[Calca; Calca; CAL6; CGRP; Cal1; Calc; RATCAL6; calcitonin; Calc; CGRP-I]

CALCA_RAT

Polyclonal

Sheep

Ammonium sulphate precipitation.

Liquid. In PBS containing 0.1% sodium azide.

Long term storage: -20°C. Shipped on blue ice. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

Test tissues: Rat thoracolumbar spinal cord. Fixatives: Recommended fixative is 4% formaldehyde(prepared from para-polymer) in 0.1M sodium phosphate buffer(pH 7.2-7.4). Perfusion fixation is recommended if possible.

Immunohistochemistry (IHC)

Immunogen: Synthetic peptide corresponding to a portion of rat alpha -calcitonin gene-related peptide (CGRP). Species reactivity: Human, Mouse, Rat, Rabbit. Cross reactivity: Likely to react with other mammalien species (based on homology, not tested).

Cell Signaling

Calcitonin gene-related peptide (CGRP) is a 37-amino acid disulphide-bridged sensory neuropeptide present in the central and peripheral nervous systems of many animal species. Two forms of CGRP ( alpha and beta ) have been identified from both rat and human, and the sequence of chicken CGRP has also been reported, showing striking structural similarity to the mammalian forms. CGRP is abundant in perivascular sensory neurons and is known to be a potent vasodilator. Recent work supports the role of CGRP in mediating skin vasodilatation and differential mesenteric artery vasorelaxation, as well as serving as an endogenous myocardial protective substance with a possible involvement in the inhibition of human platelet aggregation. CGRP is frequently co-localised with Substance P and immunoelectron microscopic observations have shown that the peptides are co-stored in single secretory granules both in sensory neurons and in thyroid C-cells. There are many hundreds of reports in the scientific literature describing the localisation and co-existence of CGRP with other transmitter molecules in a vast array of mammalian and non-mammalian species.

115485

P01256.1

P01256

Calcitonin-like Ligand Receptors Pathway (1333961); Class B/2 (Secretin Family Receptors) Pathway (1333960); G Alpha (s) Signalling Events Pathway (1333965); GPCR Downstream Signaling Pathway (1333964); GPCR Ligand Binding Pathway (1333934); Myometrial Relaxation And Contraction Pathways (198465); Signal Transduction Pathway (1333779); Signaling By GPCR Pathway (1333933)

an inhibitor of lactotroph function and a potent vasodilator [RGD, Feb 2006]

CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Cellular Component: axon; cell soma; cytoplasm; cytosol; extracellular region; extracellular space; intracellular; neuron projection; nucleus; terminal button. Molecular Function: calcitonin receptor binding; hormone activity; identical protein binding; neuropeptide hormone activity; protein complex binding; receptor binding. Biological Process: activation of protein kinase activity; adenylate cyclase activation; aging; antibacterial humoral response; antifungal humoral response; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of temperature stimulus involved in sensory perception of pain; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; endothelial cell migration; endothelial cell proliferation; feeding behavior; G-protein coupled receptor internalization; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; innate immune response; leukocyte adhesion; monocyte chemotaxis; negative regulation of blood pressure; negative regulation of bone resorption; negative regulation of neurological process; negative regulation of ossification; negative regulation of osteoclast differentiation; negative regulation of smooth muscle contraction; negative regulation of transcription, DNA-dependent; neuromuscular junction development; neuropeptide signaling pathway; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of cell adhesion; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of ossification; positive regulation of vasodilation; protein amino acid phosphorylation; receptor internalization; regulation of blood pressure; regulation of heart contraction; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; response to yeast; vasculature development; vasodilation; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure

0.025 mL

200 USD

0.1 mL

460