APRIL (human) monoclonal antibody (Aprily-2) | MyBioSource MBS565155 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

APRIL (human) monoclonal antibody (Aprily-2)

catalog :

MBS565155

quantity :

0.1 mg

price :

450 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[Aprily-2]

reactivity :

human

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Figure: Biopsy of tumor lesion from a patient with lymphoma (DLBCL) stained with MAb to APRIL (Aprily-2) . The biopsy was stained by standard immunohistochemistry. The figure shows the selective accumulation of APRIL around tumor cells.Picture courtesy of Dr. Bertrand Huard (University of Geneva).

product information

catalog number :

MBS565155

products type :

Antibody

products full name :

APRIL (human) monoclonal antibody (Aprily-2)

products short name :

[APRIL]

products name syn :

[A-Proliferation-inducing ligand; TNFSF 13; CD256]

other names :

[Tumor necrosis factor ligand superfamily member 13; Tumor necrosis factor ligand superfamily member 13; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor superfamily member 13; A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD_antigen: CD256]

products gene name :

[APRIL]

other gene names :

[TNFSF13; TNFSF13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715; APRIL; TALL2; ZTNF2; APRIL; TALL-2; TRDL-1]

uniprot entry name :

TNF13_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

[Aprily-2]

host :

Mouse

reactivity :

Human

sequence positions :

[93-233]

sequence length :

233

specificity :

Recognizes human APRIL.

form :

Liquid. In PBS containing 0.02% sodium azide.

storage stability :

Short term: 4°C. Long term: -20°C. Avoid freeze/thaw cycles. Ships on blue ice. Stable for at least 1 year after receipt when stored as recommended.

tested application :

IHC (PS)

app notes :

Immunohistochemistry (paraffin sections (1:500)). Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

image1 heading :

Testing Data

other info1 :

Source: Purified from concentrated hybridoma tissue culture supernatant. Immunogen: Recombinant human APRIL (aa 93-233).

products categories :

Cell Signaling; Cell & Tissue Markers

ncbi gi num :

13124605

ncbi acc num :

O75888.1

uniprot acc num :

O75888

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Gene Expression Pathway (1269649); HuR (ELAVL1) Binds And Stabilizes MRNA Pathway (1269730); Immune System Pathway (1269170); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway (1269725); Rheumatoid Arthritis Pathway (200309)

ncbi summary :

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

uniprot summary :

TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: cytoplasm; cytosol; external side of plasma membrane; extracellular region; extracellular space; nucleoplasm. Molecular Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding. Biological Process: gene expression; immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of isotype switching to IgA isotypes; regulation of mRNA stability; signal transduction; tumor necrosis factor-mediated signaling pathway

size1 :

0.1 mg

price1 :

450 USD

more info or order :

MyBioSource product webpage