product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
IL-33 monoclonal antibody (Nessy-1)
catalog :
MBS565002
quantity :
0.1 mg
price :
475 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[Nessy-1]
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay, immunohistochemistry - paraffin section
more info or order :
image
image 1 :
Figure: Immunohistochemical staining of endogenous human IL-33 in different human tissues (paraffin sections) using MAb to IL-33 (Nessy-1) . Method: Different human normal tissues (A: Stomach; B: Bronchus; C: Vulva/Anal skin; D: Nasopharynx) or cancer tissues (E: Colorectal cancer; F: Malignant glioma) were stained with MAb to lL-33 (Nessy-1) by standard immunohistochemistry. Pictures courtesy of Human Protein Atlas (http://www.proteinatlas.org/).
product information
catalog number :
MBS565002
products type :
Antibody
products full name :
IL-33 monoclonal antibody (Nessy-1)
products short name :
[IL-33]
products name syn :
[Interleukin-33, IL-1F11, NF-HEV]
other names :
[Interleukin-33; Interleukin-33; interleukin-33; interleukin 33; Interleukin-1 family member 11; IL-1F11]
products gene name :
[Interleukin-33; IL-1F11; NF-HEV]
other gene names :
[IL33; IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV]
uniprot entry name :
IL33_HUMAN
clonality :
Monoclonal
isotype :
IgG1 kappa
clone :
[Nessy-1]
host :
Mouse
reactivity :
Human, Mouse, Rat
sequence length :
270
specificity :
Recognizes pro-IL-33 (precursor) and mature IL-33.
purity :
Protein G-affinity purified.
form :
Liquid. In PBS containing 0.02% sodium azide.
storage stability :
Long term: Stable for at least 1 year after receipt when stored at -20 degree C. Short term: 4 degree C
tested application :
ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)
app notes :
Immunoprecipitation (1:100). Western Blot (1:1,000). Suggested dilutions/conditions may not be available for all applications.
image1 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Recombinant human IL-33 (aa 112-270). Source: Purified from ascites.
products categories :
Cell Signaling
ncbi gi num :
68565855
ncbi acc num :
O95760.1
uniprot acc num :
O95760
ncbi mol weight :
16,250 Da
ncbi pathways :
Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Influenza A Pathway (217173); Influenza A Pathway (217150)
ncbi summary :
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
uniprot summary :
IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: chromosome; extracellular space; nucleus; transport vesicle. Molecular Function: cytokine activity; protein binding. Biological Process: defense response to virus; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; negative regulation of leukocyte migration; negative regulation of T-helper 1 type immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 2 type immune response; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
size1 :
0.1 mg
price1 :
475 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!
related products
browse more products
questions and comments