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Human beta 2-Microglobulin Reference Standard

MBS563304

1 mL

175 USD

Reference Serum & Calibrator

Human beta 2-Microglobulin Reference Standard

beta 2-Microglobulin Reference Standard

Human beta 2-Microglobulin Reference Standard

beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; OTTHUMP00000161912; beta-2-microglobin; beta chain of MHC class I molecules; beta-2-microglobulin

B2M; B2M

B2MG_HUMAN

Human

Whole Serum. Physical State: Liquid

Store at -20 degree C

The level of beta 2-Microglobulin in the serum was quantified using ELISA. Concentration: 1.77 ug/ml (1/200 when used with E-80B2)

Preservative: 0.1% sodium azide. Procedure: Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C.

Reference Standard

B2M levels were determined by ELISA assay.

179318

P61769

13,715 Da

Adaptive Immunity Signaling Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); HIV Infection Pathway (105983); Host Interactions Of HIV Factors Pathway (106010)

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; extracellular region; plasma membrane; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic

1 mL

175 USD