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Human NGAL Reference Standard

MBS563300

1 mL

175 USD

Reference Serum & Calibrator

Human NGAL Reference Standard

NGAL (Lipocalin 2) Reference Standard

Human NGAL Reference Standard

neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; siderocalin; oncogene 24p3; OTTHUMP00000022238; OTTHUMP00000022239; OTTHUMP00000022240; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; lipocalin 2; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; p25

LCN2; LCN2; 24p3; MSFI; NGAL; HNL; NGAL

NGAL_HUMAN

Human

Whole Serum. Physical State: Liquid

Store at 4 degree C less that seven days, frozen for more than seven days.

The level of NGAL in the serum was quantified using ELISA. Concentration: 27.40 ng/ml (1/10 when used with E-80NGL)

Specifications: The level of NGAL in the serum was quantified using ELISA. Concentration: 61.58 ng/ml.

Preservative: 0.1% sodium azide. Procedure: Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C.

Reference Standard

NGAL levels were determined by ELISA assay.

38455402

NP_005555.2

NM_005564.3

P80188

22,588 Da

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: extracellular space; extracellular region; cytosol. Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding. Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; transmembrane transport

1 mL

175 USD