This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
other
product name :
Rat Ceruloplasmin Reference Standard
catalog :
MBS563273
quantity :
1 ml
price :
175 USD
product information
catalog number :
MBS563273
products type :
Reference Serum & Calibrator
products full name :
Rat Ceruloplasmin Reference Standard
products short name :
Ceruloplasmin Reference Standard
products name syn :
Rat Ceruloplasmin Reference Standard
other names :
ceruloplasmin; Ceruloplasmin; ceruloplasmin; OTTHUMP00000197026; OTTHUMP00000215840; OTTHUMP00000215841; ceruloplasmin (ferroxidase); Ferroxidase
other gene names :
CP; CP; CP-2
uniprot entry name :
CERU_HUMAN
host :
Rat
form :
Whole Serum. Physical State: Liquid
storage stability :
4 degree C for short-term storage or frozen for long-term storage.
app notes :
Quantified Ceruloplasmin Value = 669 ug/ml (dilute 1/20,000 when used with E-25C)
other info2 :
Preservative: 0.1% sodium azide. Procedure: Serum was collected from rats of several strains, ages and both sexes.
products categories :
Reference Standard
products description :
Pooled normal rat serum. Ceruloplasmin levels were determined by ELISA assay.
ncbi gi num :
1731685
uniprot acc num :
P00450
ncbi mol weight :
122,205 Da
ncbi pathways :
HIF-1-alpha Transcription Factor Network Pathway 138045!!Iron Uptake And Transport Pathway 187191!!Metal Ion SLC Transporters Pathway 161066!!Porphyrin And Chlorophyll Metabolism Pathway 83021!!Porphyrin And Chlorophyll Metabolism Pathway 407!!SLC-mediated Transmembrane Transport Pathway 119558!!Transmembrane Transport Of Small Molecules Pathway 106572!!Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway 119571
ncbi summary :
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. [provided by RefSeq]
uniprot summary :
Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Catalytic activity: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. Cofactor: Binds 6 copper ions per monomer. Subcellular location: Secreted. Tissue specificity: Expressed by the liver and secreted in plasma. Involvement in disease: Defects in CP are the cause of aceruloplasminemia (ACERULOP) [. MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Sequence similarities: Belongs to the multicopper oxidase family.Contains 3 F5/8 type A domains.Contains 6 plastocyanin-like domains.
size :
1 ml
price :
175 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
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