antibody

Affinity Purified Goat anti-Human SAA Antibody

MBS560674

0.1 mg

265 USD

polyclonal

goat

nonconjugated

Antibody

Affinity Purified Goat anti-Human SAA Antibody

SAA (Serum Amyloid A)

Affinity Purified Goat anti-Human SAA; anti-Human SAA (Serum Amyloid A)

serum amyloid A protein; serum amyloid A protein

SAA1; SAA

Polyclonal

Goat

Human

Unconjugated A.P.

Liquid

1mg/ml

Store at 4 degree C. Shelf Life: 24 months after shipping date

This product is monospecific to Human SAA by immunoelectrophoresis and gel diffusion techniques. Suitable for blotting and ELISA applications

Buffer: Phosphate buffered saline, pH 7.2

Preservative: 0.1% sodium azide. Procedure: Goats were immunized with highly purified recombinant Human SAA. Antiserum was collected and immunoaffinity purified off an antigen containing immunoabsorbant. Cellular Location: Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Lysosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, P-body. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. May also localize to the hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (By similarity) Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). Tissue Location : Widely expressed.

Human Protein

Goats were immunized with highly purified recombinant human SAA. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-human SAA was immunoaffinity purified. Function: Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.

93352563

NP_001035288.1

NM_001040198.1

0.1 mg

265 USD