antibody

Affinity Purified Goat anti-Human NGAL Antibody

MBS560671

0.1 mg

265 USD

polyclonal

goat

nonconjugated

Antibody

Affinity Purified Goat anti-Human NGAL Antibody

NGAL

Goat anti-Human NGAL; anti-Human NGAL

neutrophil gelatinase-associated lipocalin; Neutrophil gelatinase-associated lipocalin; neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; siderocalin; oncogene 24p3; OTTHUMP00000022238; OTTHUMP00000022239; OTTHUMP00000022240; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; lipocalin 2; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; p25

LCN2; LCN2; 24p3; MSFI; NGAL; HNL; NGAL

NGAL_HUMAN

Polyclonal

Goat

Human

Unconjugated A.P.

Liquid

Store at 4 degree C. Shelf Life: 24 months from shipment date

ELISA: Suggested dilution range 0.5 - 0.1 ug/mL

Buffer: Phosphate buffered saline, pH 7.2

Preservative: 0.1% sodium azide. Procedure: Goats were immunized with highly purified recombinant human NGAL protein. The resulting anti-human NGAL antibodies were immunoaffinity purified off an antigen containing immunoabsorbant.

Human Protein

Goats were immunized with recombinant human Lipocalin-2/NGAL. The resulting antiserum was passed over an antigen containing immunabsorbant from which the anti-human NGAL was immunoaffinity purified.

38455402

NP_005555.2

NM_005564.3

P80188

22,588 Da

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: extracellular space; extracellular region; cytosol. Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding. Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; transmembrane transport

0.1 mg

265 USD