antibody

Affinity Purified Rabbit anti-Human Haptoglobin

MBS560552

1 mg

225 USD

polyclonal

rabbit

nonconjugated

Antibody

Affinity Purified Rabbit anti-Human Haptoglobin

Haptoglobin

Affinity Purified Rabbit anti-Human Haptoglobin; anti-Human Haptoglobin

haptoglobin; Haptoglobin; haptoglobin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; haptoglobin

HP; HP; BP; HPA1S; HP2ALPHA2; MGC111141; HP

HPT_HUMAN

Polyclonal

Rabbit

Human

Unconjugated A.P.

Liquid

Store at 4 degree C. Shelf Life: 24 months after shipping date.

The affinity purified antibody forms a single precipitin band with human serum haptoglobin and purified human haptoglobin by immunoelectrophoresis and double diffusion. This product is suitable for ELISA and blotting applications.

Buffer: Phosphate buffered saline, pH 7.2

Preservative: 0.1% sodium azide. Procedure: Rabbits were immunized with human haptoglobin. After multiple immunizations the rabbits were bled, serum collected and the anti-haptoglobin was immunoaffinity purified.

Human Protein

Rabbits were immunized with highly purified human haptoglobin. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-human haptoglobin was immunoaffinity purified.

386783

P00738

45,205 Da

Amb2 Integrin Signaling Pathway (137945)

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity. Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; negative regulation of oxidoreductase activity; defense response to bacterium; acute-phase response; defense response. Disease: Anhaptoglobinemia

1 mg

225 USD