Affinity Purified Goat anti-Human Prealbumin | MyBioSource MBS560413 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Affinity Purified Goat anti-Human Prealbumin

catalog :

MBS560413

quantity :

1 mg

price :

175 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS560413

products type :

Antibody

products full name :

Affinity Purified Goat anti-Human Prealbumin

products short name :

Prealbumin

products name syn :

Affinity Purified Goat anti-Human Prealbumin; anti-Human Prealbumin

other names :

prealbumin; Transthyretin; transthyretin; ATTR; OTTHUMP00000162827; carpal tunnel syndrome 1; thyroxine-binding prealbumin; prealbumin, amyloidosis type I; transthyretin; ATTR; Prealbumin; TBPA

other gene names :

TTR; TTR; CTS; CTS1; PALB; TBPA; HsT2651; PALB

uniprot entry name :

TTHY_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human

purity :

Unconjugated A.P.

form :

Liquid

storage stability :

Store at 4 degree C. Shelf Life: 12 months from shipment date

app notes :

A single band is formed when 3ug of antibody is reacted with 75 ul of Rabbit anti-Goat Whole Serum. A single band is formed when 75 ug of antibody is reacted with 3 ul of human serum and 3 ug of purified human prealbumin. Suitable for ELISA and blotting applications

other info1 :

Buffer: Phosphate buffered saline, pH 7.2

other info2 :

Preservative: 0.1% sodium azide. Procedure: Goats were immunized with highly purified human serum prealbumin in Freund's adjuvant. The anti-Human prealbumin antibodies were immunoaffinity purified off a human prealbumin immunoabsorbant.

products categories :

Human Protein

products description :

Goats were immunized with highly purified human prealbumin. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-human prealbumin was immunoaffinity purified.

ncbi gi num :

219978

uniprot acc num :

P02766

ncbi mol weight :

15,887 Da

ncbi pathways :

Amyloids Pathway (366238); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911)

ncbi summary :

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq]

uniprot summary :

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: extracellular space; protein complex; cytoplasm; extracellular region. Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; hormone activity. Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; retinol metabolic process; transport; retinoid metabolic process. Disease: Hyperthyroxinemia, Dystransthyretinemic; Carpal Tunnel Syndrome; Amyloidosis, Hereditary, Transthyretin-related

size1 :

1 mg

price1 :

175 USD

more info or order :

MyBioSource product webpage