Affinity Purified Goat anti-Bovine Haptoglobin | MyBioSource MBS560354 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Affinity Purified Goat anti-Bovine Haptoglobin

catalog :

MBS560354

quantity :

1 mL

price :

195 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, cow

product information

catalog number :

MBS560354

products type :

Antibody

products full name :

Affinity Purified Goat anti-Bovine Haptoglobin

products short name :

Haptoglobin

products name syn :

Goat anti-Bovine Haptoglobin; anti-Bovine Haptoglobin

other names :

haptoglobin; Haptoglobin; haptoglobin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; haptoglobin

other gene names :

HP; HP; BP; HPA1S; HP2ALPHA2; MGC111141; HP

uniprot entry name :

HPT_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Bovine

form :

Liquid

storage stability :

Store at 4 degree C. Shelf Life: 24 months from shipment date

app notes :

The antiserum only reacts with a single protein in the serum from some cows, calves, bulls and steers. This protein has the molecular characteristics of bovine haptoglobin and weakly cross reacts with some anti human haptoglobin antibodies. It is important to know that most "true normal, healthy" cattle have only a few micrograms/ml of haptoglobin. The level of haptoglobin elevates dramatically during acute phase inflammatory insults. Suitable for RID (start at 8%), immunodiffusion and IEP procedures.

other info2 :

Preservative: 0.1% sodium azide. Procedure: Goats were immunized with purified bovine haptoglobin, isolated from the serum of calves shown to have high levels of haptoglobin, in Freund's adjuvant. The resulting antiserum was solid phase absorbed with bovine serum lacking detectable haptoglobin.

products categories :

Bovine Protein

products description :

The antiserum only reacts with a single protein in the serum from some cows, calves, bulls and steers. This protein has the molecular characteristics of bovine haptoglobin and weakly cross reacts with some anti human haptoglobin antibodies. It is important to know that most “true normal, healthy” cattle have only a few micrograms/ml of haptoglobin. The level of haptoglobin elevates dramatically during acute phase inflammatory insults. Suitable for RID (start at 8%), immunodiffusion and IEP procedures.

ncbi gi num :

386783

uniprot acc num :

P00738

ncbi mol weight :

45,205 Da

ncbi pathways :

Amb2 Integrin Signaling Pathway (137945)

ncbi summary :

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

uniprot summary :

HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 16q22.2. Cellular Component: extracellular space; extracellular region. Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity. Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; immune system process; metabolic process; defense response to bacterium; negative regulation of oxidoreductase activity; acute-phase response; defense response. Disease: Anhaptoglobinemia

size1 :

1 mL

price1 :

195 USD