catalog number :
MBS560230
products full name :
Goat anti-Human Alpha 1-Antichymotrypsin
products short name :
alpha 1-Antichymotrypsin
products name syn :
Goat anti-Human Alpha 1-Antichymotrypsin; anti-Human alpha 1-Antichymotrypsin
other names :
alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin; alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; Serpin A3
other gene names :
SERPINA3; SERPINA3; ACT; AACT; GIG24; GIG25; MGC88254; AACT
uniprot entry name :
AACT_HUMAN
form :
Whole Serum. Physical State: Liquid
concentration :
4.0mL (2 vials): 2.0ml each
storage stability :
Store at 4 degree C. Shelf Life: 12 months from shipment date
app notes :
The anti-Human Alpha 1-Antichymotrypsin forms a single precipitin arc against purified human Alpha 1-Antichymotrypsin by immunoelectrophoresis.
other info2 :
Preservative: 0.1% sodium azide. Procedure: Goats were immunized with highly purified human Alpha 1-Antichymotrypsin. After multiple immunizations the goats were bled and antiserum was collected. The antiserum was then solid phase absorbed to ensure specificity to human Alpha 1-Antichymotrypsin.
products categories :
Human Protein
products description :
Goats were immunized with highly purified human Alpha 1-Antichymotrypsin. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-human Alpha 1-Antichymotrypsin was immunoaffinity purified.
ncbi acc num :
NP_001076.2
ncbi gb acc num :
NM_001085.4
ncbi mol weight :
47,651 Da
ncbi pathways :
Selenium Pathway (198825)
ncbi summary :
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]
uniprot summary :
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: extracellular space; extracellular region; intracellular; nucleus. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding. Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response