antibody

Affinity Purified Goat anti-Dog CRP

MBS560221

1 mL

160 USD

polyclonal

goat

nonconjugated

human, dog

Antibody

Affinity Purified Goat anti-Dog CRP

CRP

Goat anti-Dog CRP (C- Reactive Protein); anti-Dog CRP

CRP; C-reactive protein; C-reactive protein; pentraxin 1; OTTHUMP00000033307; C-reactive protein, pentraxin-related

CRP; CRP; PTX1; MGC88244; MGC149895; PTX1

CRP_HUMAN

Polyclonal

Goat

Dog

Whole Serum. Physical State: Liquid

Store at 4 degree C, frozen for long-term storage. Shelf Life: 12 months from shipment date

C-Reactive Protein (CRP) is one of the major acute phase proteins involved in acute reactions to trauma, infections, certain malignancies and other inflammatory processes. Measurement of CRP can indicate the presence and severity of certain clinical situations and monitor the results of treatments. Goat anti CRP gives a single band by IEP and gel diffusion against fluids with high levels of CRP. For RID we recommend a 5-10% plate.

Preservative: 0.1% sodium azide. Procedure: Goats located in the USA were immunized with highly purified dog crp isolated from the serum of dogs with abnormally high crp. The resulting antiserum was solid phase absorbed with dog serum lacking crp until it gave a single band with serum containing the acute phase protein.

Dog Protein

Goats were immunized with highly purified dog CRP. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-dog CRP was immunoaffinity purified.

17975775

P02741

25,039 Da

Classical Antibody-mediated Complement Activation Pathway (106409); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immunity Signaling Pathway (106387); Selenium Pathway (198825)

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq]

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q23.2. Cellular Component: extracellular space; growth cone; extracellular region; filopodium. Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; cholesterol binding; low-density lipoprotein binding; virion binding; calcium ion binding. Biological Process: protein polymerization; wound healing; defense response to Gram-positive bacterium; response to ethanol; negative regulation of vasodilation; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging

1 mL

160 USD