Tyrosine Hydroxylase | MyBioSource MBS555890 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Tyrosine Hydroxylase

catalog :

MBS555890

quantity :

0.1 mL

price :

405 USD

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunofluorescent analysis of rat brain section stained with chicken antibody to tyrosine hydroxylase, MBS555890, dilution 1:5,000 in green. The blue is Hoechst staining of nuclear DNA. MBS555890 stains the dopaminergic TH-positive neurons and their processes of substantia nigra

product information

catalog number :

MBS555890

products type :

Antibody

products full name :

Tyrosine Hydroxylase

products short name :

[Tyrosine Hydroxylase]

other names :

[tyrosine 3-monooxygenase isoform b; Tyrosine 3-monooxygenase; tyrosine 3-monooxygenase; tyrosine hydroxylase; Tyrosine 3-hydroxylase]

other gene names :

[TH; TH; TYH; DYT14; DYT5b; TYH; TH]

uniprot entry name :

TY3H_HUMAN

clonality :

Polyclonal

host :

Chicken

reactivity :

Human, Mouse, Rat

form :

Purified antibody at 1 mg/ml in 50% glycerol plus 5mM of Sodium Azide

storage stability :

Antibody can also be aliquotted and stored frozen at -20°C in a manual defrost freezer for six months without detectable loss of activity. The antibody can be stored at 2° - 8°C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunocytochemistry (ICC), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Immunofluorescence: 1:5,000. Immunohistochemistry: 1:5,000. Immunocytochemistry: 1:5,000. Western Blot: 1:50,000. Dilutions listed as a recommendation. Optimal dilution should be determined by investigator.

image1 heading :

Immunofluorescence (IF)

other info1 :

Immunogen Sequence: Full length human tyrosine hydroxylase as expressed in and purified E. coli

products description :

Tyrosine Hydroxylase (TH) is a vital enzyme in the generation of L-DOPA from the amino acid tyrosine. TH expression is restricted in the brain, but expressed highly in locations where it is found. TH antibody are useful in identifying chatecholaminergic neurons. This antibody was made against full length human recombinant human tyrosine hydroxylase.

ncbi gi num :

88900503

ncbi acc num :

NP_000351.2

ncbi gb acc num :

NM_000360.3

uniprot acc num :

P07101

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha-synuclein Signaling Pathway (137913); Amine-derived Hormones Pathway (160983); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Biogenic Amine Synthesis Pathway (198793); Catecholamine Biosynthesis Pathway (160984); Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway (413357)

ncbi summary :

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Protein type: Oxidoreductase; Endoplasmic reticulum; Mitochondrial; Vesicle; Amino Acid Metabolism - tyrosine; EC 1.14.16.2. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: internal side of plasma membrane; neuron projection; smooth endoplasmic reticulum; mitochondrion; melanosome membrane; dendrite; terminal button; perikaryon; cytosol; synaptic vesicle; cytoplasm; cytoplasmic vesicle; nucleus. Molecular Function: protein domain specific binding; amino acid binding; protein binding; enzyme binding; ferric iron binding; ferrous iron binding; dopamine binding; oxygen binding; tyrosine 3-monooxygenase activity. Biological Process: heart morphogenesis; heart development; response to lipopolysaccharide; dopamine biosynthetic process; phytoalexin metabolic process; norepinephrine biosynthetic process; dopamine biosynthetic process from tyrosine; catecholamine biosynthetic process; response to electrical stimulus; epinephrine biosynthetic process; response to pyrethroid; neurotransmitter biosynthetic process; response to corticosterone stimulus; response to light stimulus; anatomical structure morphogenesis; phthalate metabolic process; mating behavior; social behavior; eye photoreceptor cell development; organ morphogenesis; response to ethanol; circadian sleep/wake cycle; response to zinc ion; cerebral cortex development; response to activity; response to water deprivation; synaptic transmission, dopaminergic; response to peptide hormone stimulus; locomotory behavior; fatty acid metabolic process; response to salt stress; response to estradiol stimulus; regulation of heart contraction; sensory perception of sound; visual perception; glycoside metabolic process; response to nutrient levels; terpene metabolic process; sphingolipid metabolic process; eating behavior; response to amphetamine; multicellular organismal aging; isoquinoline alkaloid metabolic process; response to herbicide; learning; response to ether; synaptic vesicle amine transport; memory; pigmentation; response to hypoxia; embryonic camera-type eye morphogenesis. Disease: Segawa Syndrome, Autosomal Recessive

size1 :

0.1 mL

price1 :

405 USD

more info or order :

MyBioSource product webpage