Rabbit Polyclonal Anti-Glutamine Synthase | MyBioSource MBS555124 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal Anti-Glutamine Synthase

catalog :

MBS555124

quantity :

0.1 mL

price :

395 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS555124

products type :

Antibody

products full name :

Rabbit Polyclonal Anti-Glutamine Synthase

products short name :

[Glutamine Synthase]

other names :

[glutamine synthetase; Glutamine synthetase; glutamine synthetase; glutamate-ammonia ligase; Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase]

other gene names :

[GLUL; GLUL; GS; GLNS; PIG43; PIG59; GLNS; GS]

uniprot entry name :

GLNA_HUMAN

clonality :

polyclonal

host :

rabbit

reactivity :

Bovine, Human, Mouse, Rat

sequence length :

373

form :

Whole serum with 0.05% Sodium Azide.

storage stability :

Store frozen. Aliquot as undiluted antisera and immediately place at -20 degree C. Antisera may have become trapped in top of vial during shipping. Centrifugation of vial is recommended before opening. Stable for at least 6 months at -20 degree C. Repeated freeze/thaw cycles compromise the integrity of the antiserum.

tested application :

Immunohistochemistry (IHC), Western Blot (WB)

app notes :

Western Blot (WB): 1:1000. Immunohistochemistry (IHC): 1:25,000 with ABC amplification. Dilutions listed as a recommendation. Optimal dilution should be determined by investigator.

image1 heading :

Testing Data

image2 heading :

Western Blot (WB)

other info1 :

Type Info: Rabbit IgG

other info2 :

Immunogen: Recombinant Protein

products categories :

Glutamine Synthetase

products description :

Glutamine Synthetase, also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. The enzyme clears L-glutamate, the major neurotransmitter in the central nervous system, from neuronal synapses.

ncbi gi num :

74271837

ncbi acc num :

NP_001028216.1

ncbi gb acc num :

NM_001033044.3

ncbi mol weight :

42,064 Da

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (1270159); Arginine Biosynthesis Pathway (82943); Arginine Biosynthesis Pathway (306); Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway (1268785); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); GABA Shunt Pathway (142350); GABAergic Synapse Pathway (377263)

ncbi summary :

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

uniprot summary :

GLUL: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. Essential for proliferation of fetal skin fibroblasts. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD). CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Belongs to the glutamine synthetase family. Protein type: EC 6.3.1.2; Ligase; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; Amino Acid Metabolism - alanine, aspartate and glutamate; Energy Metabolism - nitrogen. Chromosomal Location of Human Ortholog: 1q31. Cellular Component: protein complex; mitochondrion; rough endoplasmic reticulum; cytoplasm; perikaryon; nerve terminal; nucleus; cytosol. Molecular Function: glutamate-ammonia ligase activity; identical protein binding; dynein light chain binding; glutamate binding; glutamate decarboxylase activity; manganese ion binding; magnesium ion binding; ATP binding. Biological Process: glutamate catabolic process; cell proliferation; synaptic transmission; glutamine biosynthetic process; response to glucose stimulus; positive regulation of insulin secretion; neurotransmitter uptake; amino acid biosynthetic process; cellular response to starvation; positive regulation of synaptic transmission, glutamatergic; positive regulation of epithelial cell proliferation; protein homooligomerization. Disease: Glutamine Deficiency, Congenital

size1 :

0.1 mL

price1 :

395 USD

more info or order :

MyBioSource product webpage