Human IL-17RC Fc tagged Recombinant | MyBioSource MBS553345 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human IL-17RC Fc tagged Recombinant

catalog :

MBS553345

quantity :

0.02 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553345

products type :

Recombinant Protein

products full name :

Human IL-17RC Fc tagged Recombinant

products short name :

IL-17RC Fc tagged

products name syn :

Human IL-17RC Fc tag Recombinant; il-17rc; il17Rc; interleukin-17 r

other names :

interleukin-17 receptor C isoform 4; Interleukin-17 receptor C; Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14

products gene name :

IL17RC

products gene name syn :

IL-17R

other gene names :

IL17RC; IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL

uniprot entry name :

I17RC_HUMAN

host :

HEk293 Cells

sequence length :

707

purity :

>98%, as determined by SDS-PAGE and HPLC

form :

Recombinant Interleukin-17RC is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant IL-17RC, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Host Note: Optimized DNA sequence encoding extracellular domain of human IL-17RC receptor including a C terminal Human IgG1 Fc tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant IL17RC-Fc is a homodimer protein consisting of 675 amino acid residue subunits, due to glycosylation migrates as an approximately 100kD protein under reducing SDS-PAGE conditions.

products categories :

Receptors CD

products description :

IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow and spleen, as well as expansion of mature neutrophils in peripheral blood. IL-17RA signaling up- regulates production of neutrophilic chemokines such as CXCL1 (KC), CXCL2, CXCL5, CXCL6, and CXCL8, which in turn regulate neutrophil emigration to mucosal sites. Due to this role in neutrophil expansion and recruitment, IL-17RA signaling is an important part of the host response to extracellular bacterial infections.To date, four additional receptors have been identified in the IL- 17R family based on sequence homology to IL-17R (IL- 17Rh1, IL-17RC, IL-17RD, and IL-17RE) and among them, IL- 17RC has been shown recently to physically associate with IL-17RA, suggesting that it may be a functional component in the IL-17R complex. Nevertheless, the final structure of the functional IL-17 receptor and the mechanisms of interactions with IL-17A remain unknown.

products references :

il-17a and IL-17RC expression in the macula of the human eye with age-related macular degeneration . Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 1667. il-17a- versus il-17f-induced intracellular signal transduction pathways and modulation by il-17ra and IL-17RC rna interference in rheumatoid synoviocytes . Ann Rheum Dis, Feb 2011; 70: 341 - 348. IL-17RC is required for immune signaling via an extended sef/il-17r signaling domain in the cytoplasmic tail . J. Immunol., Jul 2010; 185: 1063 - 1070. IL-17RC is required for il-17a and il-17f dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis . J. Immunol., Apr 2010; 184: 4307 - 4316. the human il-17f/il-17a heterodimeric cytokine signals through the il-17ra/ IL-17RC receptor complex . J. Immunol., Aug 2008; 181: 2799 - 2805.

ncbi gi num :

322812168

ncbi acc num :

NP_001190192.1

ncbi gb acc num :

NM_001203263.1

uniprot acc num :

Q8NAC3

ncbi mol weight :

86,240 Da

ncbi summary :

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

uniprot summary :

IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 3p25.3 3p25.3-p24.1. Cellular Component: integral to plasma membrane. Molecular Function: interleukin-17 receptor activity. Biological Process: cytokine and chemokine mediated signaling pathway. Disease: Candidiasis, Familial, 9

size1 :

0.02 mg

price1 :

220 USD

size2 :

0.1 mg

price2 :

595

size3 :

0.5 mg

price3 :

2220

more info or order :

MyBioSource product webpage