Human IL-3 receptor Recombinant (CD123) | MyBioSource MBS553344 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human IL-3 receptor Recombinant (CD123)

catalog :

MBS553344

quantity :

0.01 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553344

products type :

Recombinant Protein

products full name :

Human IL-3 receptor Recombinant (CD123)

products short name :

IL-3 receptor (CD123)

products name syn :

Human IL-3R alpha Recombinant (CD123) ; CD123; IL-3Ra; IL3R; IL3RA; IL1R2

other names :

interleukin-3 receptor subunit alpha isoform 2; Interleukin-3 receptor subunit alpha

products gene name :

IL3RA

products gene name syn :

IL-3RA

other gene names :

IL3RA; IL3R; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA

uniprot entry name :

IL3RA_HUMAN

host :

HEk293 Cells

sequence length :

300

purity :

>97%, as determined by SDS-PAGE and HPLC

form :

Recombinant Human IL-3 receptor alpha (CD123) is lyophilized from 0.2 um filtered PBS solution, pH7.2, 5% Trehalose.

storage stability :

Recombinant Human IL3RA can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding Human extracellular domain of human IL-3 receptor alpha chain including a C-terminal His tag was expressed in HEK293 cells. Biological Activity: Recombinant Human IL-3 receptor alpha activity was measured using Immobilized human IL3 at 20ug/ml ability to bind biotinylated human IL3RA with a linear ranger of 0.32 - 1.6ug/ml

other info2 :

Molecular Weight Note: Recombinant IL-3RA (CD123) is a protein consisting of 298 amino acid residue subunits, due to glycosylation migrates as an approximately 50 kDa protein on SDS-PAGE. Endotoxin Level: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug)

products categories :

Receptors CD

products description :

CD123 is an subunit of a heterodimer IL-3 receptor, a member of the cytokine receptor superfamily. It is a 70 kDa protein, which binds IL-3 with high specificity but with low affinity. CD123 is encoded by the IL-3a gene, located in the pseudo-autosomal region (PAR) at the ends of the short arms of the X and Y chromosomes, B-lymphoid blasts from acute lymphoblastic leukemia (ALL) have been shown to express functional CD123 and CD40 ligand stimulates proliferation of precursor-B (pre-B) ALL by upregulating CD123 expression.

products references :

pellino 2 is critical for toll-like receptor/interleukin-1 receptor (tlr/ IL-1R ) -mediated post-transcriptional control . J. Biol. Chem., Jul 2012; 287: 25686 - 25695. role of toll interleukin-1 receptor ( IL-1R ) 8, a negative regulator of IL-1R /toll-like receptor signaling, in resistance to acute pseudomonas aeruginosa lung infection . Infect. Immun., Jan 2012; 80: 100 - 109. IL-1R associated kinase-1 mediates protein kinase c-induced il-1 production in monocytes . J. Immunol., Sep 2011; 187: 2632 - 2645. effect of mitomycin c on IL-1R expression, il-1 related hepatocyte growth factor secretion and corneal epithelial cell migration . Invest. Ophthalmol. Vis. Sci., Mar 2010; 51: 1389 - 1396. mycobacterium bovis bacillus calmette-gu rin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo t cell priming via IL-1R dependent nitric oxide production . J. Immunol., Feb 2010; 184: 2038 - 2047.

ncbi gi num :

391224440

ncbi acc num :

NP_001254642.1

ncbi gb acc num :

NM_001267713.1

uniprot acc num :

P26951

ncbi mol weight :

43,330 Da

ncbi summary :

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

uniprot summary :

IL3RA: This is a receptor for interleukin-3. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3. Cellular Component: integral to membrane; plasma membrane. Molecular Function: interleukin-3 receptor activity

size1 :

0.01 mg

price1 :

220 USD

size2 :

0.05 mg

price2 :

685

size3 :

0.5 mg

price3 :

4180

more info or order :

MyBioSource product webpage