protein

Human Follistatin Recombinant

MBS553343

0.002 mg

145 USD

Recombinant Protein

Human Follistatin Recombinant

Follistatin

fst; follicle; follistatin

follistatin isoform FST317; Follistatin; Activin-binding protein

FST

FST; FS

FST_HUMAN

HEk293 Cells

317

>95%, as determined by SDS-PAGE and HPLC

Recombinant Human Follistatin was lyophillized at 1mg/ml containing no additives.

Upon reconstitution, this protein can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for 12 months without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Domain: Follistatin

Biological Activity: The ED(50) was determined by the ability to neutralize Activin A inhibitory effect of mouse MPC-11 and was determined to be 0.1-0.4 ug/ml in the presence of 7.5 ng/ml Activin A. Edotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug)

Cytokines

structure of myostatin follistatin -like 3: n-terminal domains of follistatin -type molecules exhibit alternate modes of binding . J. Biol. Chem., Jan 2012; 287: 1043 - 1053. the type 1 insulin-like growth factor receptor (igf-ir) pathway is mandatory for the follistatin -induced skeletal muscle hypertrophy . Endocrinology, Jan 2012; 153: 241 - 253. short-term energy deprivation alters activin a and follistatin but not inhibin b levels of lean healthy women in a leptin-independent manner . J. Clin. Endocrinol. Metab., Dec 2011; 96: 3750 - 3758. the expression of activins, their type ii receptors and follistatin in human fallopian tube during the menstrual cycle and in pseudo-pregnancy . Hum. Reprod., Dec 2011; 26: 3346 - 3354. energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin a and follistatin but not myostatin in healthy males . J. Clin. Endocrinol. Metab., Nov 2011; 96: 3416 - 3423.

5453652

NP_006341.1

NM_006350.3

P19883

Native human Follistatin, generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 31 kDa. Recombinant Follistatin is a disulfide-linked monomer protein consisting of 296 amin

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: cytoplasm; extracellular region; nucleus. Molecular Function: heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding. Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; keratinocyte proliferation; skeletal development; pattern specification process; female gonad development; odontogenesis of dentine-containing teeth. Disease: Polycystic Ovary Syndrome 1

0.002 mg

145 USD

0.01 mg

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