Human IL-13 alpha 1 receptor Fc tag Recombinant (IL13RA1) | MyBioSource MBS553333 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human IL-13 alpha 1 receptor Fc tag Recombinant (IL13RA1)

catalog :

MBS553333

quantity :

0.05 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553333

products type :

Recombinant Protein

products full name :

Human IL-13 alpha 1 receptor Fc tag Recombinant (IL13RA1)

products short name :

IL-13 alpha 1 receptor Fc tag (IL13RA1)

products name syn :

Human IL-13 alpha 1 receptor Fc tag Recombinant ; IL13RA1; IL-13RA1; CD213a1

other names :

interleukin-13 receptor subunit alpha-1; Interleukin-13 receptor subunit alpha-1; Cancer/testis antigen 19

products gene name :

IL13RA1

products gene name syn :

IL-13 R

other gene names :

IL13RA1; IL13R; IL13RA; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; CT19

uniprot entry name :

I13R1_HUMAN

host :

HEk293 Cells

sequence length :

427

purity :

>98%, as determined by SDS-PAGE and HPLC

form :

Recombinant IL-13 receptor alpha 1 is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant IL13RA1, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Biological Activity: The activity was tested by immobilized recombinant human IL-13 (4ug/ml) ability to bind recombinant human IL-13RA1 with a linear range of 0.1-2.5 ug/ml in functional ELISA. Host Note: Optimized DNA sequence encoding extracellular domain of human IL-13 receptor alpha 1 including a C terminal His tag and Fc tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant IL-13RA1 is a homodimer protein consisting of two 570 amino acid residue subunits, due to glycosylation migrates as an approximately 90kDa protein on SDS-PAGE.

products categories :

Receptors CD

products description :

The biological activity of IL-13 is regulated via the IL-13R type I and type II. The type I receptor is a heterodimer of the IL-4R chain (IL-4R ) and IL-13R 1, and ligand-receptor interactions induce phosphorylation of the IL- 4R and subsequent activation of the signal transducers and activators of transcription (STAT) -6 signaling pathway. This pathway appears to be the primary pathway for IL-13- induced signaling in nonhematopoietic cells. The type II receptor is composed of IL-13R 1 and IL-13R 2. IL-13R 2 binds IL-13 with high affinity and is proposed to act as a decoy receptor that limits the activity of IL-13. Consistent with this, mice deficient in IL-13R 2 demonstrate exaggerated IL- 13-induced pathologies. IL- 13R 2 possesses a short cytoplasmic tail and is without signal motifs; however, there have been a number of reports to suggest IL-13 signals through this chain, possibly via a STAT6- independent, AP-1-dependent manner to induce activation of the Tgf 1 promoter via the IL-13 type II receptor.

products references :

IL-13R 2 has a protective role in a mouse model of cutaneous inflammation . J. Immunol., Dec 2010; 185: 6802 - 6808. IL-13R 2 membrane and soluble isoforms differ in humans and mice . J. Immunol., Dec 2009; 183: 7870 - 7876. tuning sensitivity to il-4 and il-13: differential expression of il-4r, IL-13R 1, and c regulates relative cytokine sensitivity . J. Exp. Med., Oct 2008; 205: 2595 - 2608. novel role of il-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R -directed cytotoxin in a rat model . J. Immunol., Oct 2008; 181: 4656 - 4665. targeting IL-13R 2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated pseudomonas exotoxin . Mol. Cancer Ther., Jun 2008; 7: 1579 - 1587.

ncbi gi num :

4504647

ncbi acc num :

NP_001551.1

ncbi gb acc num :

NM_001560.2

uniprot acc num :

P78552

ncbi mol weight :

48,760 Da

ncbi summary :

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

uniprot summary :

IL13R: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Belongs to the type I cytokine receptor family. Type 5 subfamily. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: Xq24. Cellular Component: interleukin-13 receptor complex; plasma membrane. Molecular Function: protein binding; interleukin-13 receptor activity. Biological Process: positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; positive regulation of B cell proliferation

size1 :

0.05 mg

price1 :

220 USD

size2 :

0.2 mg

price2 :

595

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage