Mouse IL-6 Receptor Recombinant (IL-6R) | MyBioSource MBS553305 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Mouse IL-6 Receptor Recombinant (IL-6R)

catalog :

MBS553305

quantity :

0.01 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553305

products type :

Recombinant Protein

products full name :

Mouse IL-6 Receptor Recombinant (IL-6R)

products short name :

[IL-6 Receptor (IL-6R)]

products name syn :

[Mouse CD126 Recombinant (IL6 Receptor) ; cd-126 IL6R; CD126; IL-6R-1; IL-6R-alpha; IL6RA; MGC104991; IL6 Receptor]

other names :

[interleukin-6 receptor subunit alpha; Interleukin-6 receptor subunit alpha; IL-6R 1]

products gene name :

[CD126]

other gene names :

[Il6ra; Il6r; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA]

uniprot entry name :

IL6RA_MOUSE

sequence length :

460

purity :

>97%, as determined by SDS-PAGE

form :

Recombinant Mouse Interleukin-6 receptor (CD126) is supplied as a 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant Mouse IL-6R as supplied can be stored in working aliquots at 2-8°C for one month, or at -20°C to -70°C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Host Note: Optimized DNA sequence encoding extracellular domain of mouse IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells. Molecular Weight: Recombinant mouse IL-6 (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL.This solution can then be diluted into other buffers.

products categories :

Receptors CD

products description :

The effects of IL-6 are mediated by a functional IL- 6 receptor (IL-6R), which consists in a heterodimer formed by an IL-6-binding chain (IL-6R ) and a signal- transducing subunit, gp130 or IL-6R . Binding of IL-6 to the IL-6R induces homodimerization of two gp130 molecules, leading to intracellular signals.

products references :

anti-inflammatory effect of IL-6 receptor blockade on experimental corneal alkali burn . Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 4206. exposure-response relationship of tocilizumab, an anti IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis . J. Clin. Pharmacol., Feb 2012; 10.1177/0091270012437585. impact of IL-6 receptor inhibition on human memory b cells in vivo: impaired somatic hypermutation in preswitch memory b cells and modulation of mutational targeting in memory b cells . Ann Rheum Dis, Aug 2011; 70: 1507 - 1510. species specificity of adam10 and adam17 proteins in interleukin-6 (il-6) trans-signaling and novel role of adam10 in inducible IL-6 receptor shedding . J. Biol. Chem., Apr 2011; 286: 14804 - 14811. anti- IL-6 receptor antibody (tocilizumab) : a b cell targeting therapy . Ann Rheum Dis, Mar 2011; 70: A57 - A58.

ncbi gi num :

110431356

ncbi acc num :

NP_034689.2

ncbi gb acc num :

NM_010559.2

uniprot acc num :

P22272

uniprot summary :

IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Cellular Component: extracellular space; cell surface; membrane; apical plasma membrane; integral to membrane; extracellular region; interleukin-6 receptor complex. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein homodimerization activity; interleukin-6 receptor binding; enzyme binding; interleukin-6 binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity. Biological Process: negative regulation of collagen biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; endocrine pancreas development; positive regulation of chemokine production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; cell growth

size1 :

0.01 mg

price1 :

220 USD

size2 :

0.05 mg

price2 :

540

size3 :

0.5 mg

price3 :

2835

more info or order :

MyBioSource product webpage