Mouse IL-11 receptor alpha Recombinant | MyBioSource MBS553276 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Mouse IL-11 receptor alpha Recombinant

catalog :

MBS553276

quantity :

0.1 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553276

products type :

Recombinant Protein

products full name :

Mouse IL-11 receptor alpha Recombinant

products short name :

IL-11 receptor alpha

products name syn :

IL-11RA; IL11ra

other names :

interleukin-11 receptor subunit alpha-1; Interleukin-11 receptor subunit alpha-1; Enhancer trap locus homolog 2; Etl-2; Novel cytokine receptor 1

products gene name :

IL11RA

products gene name syn :

IL-11

other gene names :

Il11ra1; Etl2; Il11ra; IL-11 receptor subunit alpha-1; IL-11R subunit alpha-1; IL-11R-alpha-1; IL-11RA1; Etl-2; NR-1; NR1

uniprot entry name :

I11RA_MOUSE

host :

HEK Cells

sequence length :

432

sequence :

MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG VSAGTPVSWF RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV SGGMVTLKLG FPPARPEVSC QAVDYENFSC TWSPGQVSGL PTRYLTSYRK KTLPGAESQR ESPSTGPWPC PQDPLEASRC VVHGAEFWSE YRINVTEVNP LGASTCLLDV RLQSILRPDP PQGLRVESVP GYPRRLHASW TYPASWRRQP HFLLKFRLQY RPAQHPAWST VEPIGLEEVI TDAVAGLPHA VRVSARDFLD AGTWSAWSPE AWGTPSTGPL QDEIPDWSQG HGQQLEAVVA QEDSPAPARP SLQPDPRPLD HRDPLEQVAV LASLGIFSCL GLAVGALALG LWLRLRRSGK DGPQKPGLLA PMIPVEKLPG IPNLQRTPEN FS

purity :

>85%, as determined by SDS-PAGE and HPLC

form :

Recombinant mouse Interleukin-11receptor alpha was lyophilized from a 0.2 um filtered PBS solution pH 7.4.

storage stability :

The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Extracellular. Host Note: DNA sequence encoding extracellular domain of Mouse IL-11RA fused to a C-terminal polyHis tag was expressed in HEK cells. Biological Activity: The activity was determined by its ability to bind mouse IL-6ST in functional ELISA.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Molecular Weight Note: Recombinant Mouse Interleukin-11RA is a monomer consisting of 355 amino acid residue subunits, and migrates as an approximately 46 kDa protein under reducing conditions in SDS-PAGE. Presentation: Recombinant mouse Interleukin-11 alpha was lyophilized from a 0.2um filtered PBS solution pH 7.4.

products categories :

Receptors CD

products description :

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.

products references :

il-11 receptor in the pathogenesis of il-13-induced inflammation and remodeling . J. Immunol., Feb 2005; 174: 2305 - 2313. recombinant soluble interleukin-11 (il-11) receptor -chain can act as an il-11 antagonist . Blood, Dec 1997; 90: 4403 - 4412.

ncbi gi num :

254281269

ncbi acc num :

NP_001156873.1

ncbi gb acc num :

NM_001163401.1

uniprot acc num :

Q64385

ncbi mol weight :

46,655 Da

uniprot summary :

IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: membrane; integral to membrane. Molecular Function: interleukin-11 binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-11 receptor activity. Biological Process: maternal process involved in pregnancy; natural killer cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; decidualization; placenta development

size1 :

0.1 mg

price1 :

220 USD

size2 :

0.5 mg

price2 :

745

size3 :

1 mg

price3 :

1155

more info or order :

MyBioSource product webpage