Mouse IL-1 receptor type II Recombinant (CD121b) | MyBioSource MBS553264 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Mouse IL-1 receptor type II Recombinant (CD121b)

catalog :

MBS553264

quantity :

0.05 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553264

products type :

Recombinant Protein

products full name :

Mouse IL-1 receptor type II Recombinant (CD121b)

products short name :

[IL-1 receptor type II (CD121b)]

products name syn :

[Mouse IL-1 receptor type II Recombinant; CD121B; D2S1473; IL-1R1; IL1R2; IL1RB; P80; IL1R2]

other names :

[interleukin-1 receptor type 2; Interleukin-1 receptor type 2; CD121 antigen-like family member B; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II]

products gene name :

[IL1R2]

products gene name syn :

[IL-1R2]

other gene names :

[Il1r2; Il-1r2; Il1rb; IL-1R-2; IL-1RT-2; IL-1RT2; IL-1R-beta; mIL-1R2; mIL-1RII; sIL-1R2; sIL-1RII]

uniprot entry name :

IL1R2_MOUSE

sequence length :

410

purity :

>97%, as determined by SDS-PAGE and HPLC

storage stability :

Recombinant Mouse IL1R2 can be stored in working aliquots at 2°C- 8°C for one month, or at -20°C to -70°C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Source: Optimized DNA sequence encoding Mouse extracellular domain of mouse IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells

other info2 :

Biological Activity: Measured in an ELISA assay . The ability of mouse IL1R2 (10ug/ml) to bind biotinylated human IL1B was determined to be 0.5 ug/ml. Molecular weight: Recombinant mouse IL-1 receptor type II (CD121b) is a protein consisting of 350 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE. Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug). Presentation: Recombinant Mouse IL-1 receptor II (CD121b) is lyophilized from 0.2 um filtered PBS solution, pH7.2 , 5% Trehalose,0.01% tween80

products categories :

Receptors CD

products description :

Two distinct IL-lRs have been identified, termed type I and type II. The type I IL-lR is an 80-kDa glycoprotein found predominantly on T cells and fibroblasts, whereas the type II IL-lR is a 60- to 65-kDa molecule that is expressed on activated T cells, B cells, monocytes, and neutrophils. Evidence suggests that the type II IL-lR is not signal- transducing, and its function on the cell surface is unknown. The action of IL-1 is modulated not only by IL-lra but also by the release of a type II soluble IL-iR (sIL-lR). This 47-kDa soluble receptor is present in normal human plasma, serum, and synovial inflammatory exudate and in culture supernatants of activated peripheral blood mononuclear cells and neutrophils. sIL-lR is also released from the human B-cell Burkitt lymphoma cell line Raji, which expresses only type II IL-1R.

products references :

pellino 2 is critical for toll-like receptor/interleukin-1 receptor (tlr/ IL-1R ) -mediated post-transcriptional control . J. Biol. Chem., Jul 2012; 287: 25686 - 25695. role of toll interleukin-1 receptor ( IL-1R ) 8, a negative regulator of IL-1R /toll-like receptor signaling, in resistance to acute pseudomonas aeruginosa lung infection . Infect. Immun., Jan 2012; 80: 100 - 109. IL-1R associated kinase-1 mediates protein kinase c-induced il-1 production in monocytes . J. Immunol., Sep 2011; 187: 2632 - 2645. effect of mitomycin c on IL-1R expression, il-1 related hepatocyte growth factor secretion and corneal epithelial cell migration . Invest. Ophthalmol. Vis. Sci., Mar 2010; 51: 1389 - 1396. mycobacterium bovis bacillus calmette-gu rin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo t cell priming via IL-1R dependent nitric oxide production . J. Immunol., Feb 2010; 184: 2038 - 2047.

ncbi gi num :

6754330

ncbi acc num :

NP_034685.1

ncbi gb acc num :

NM_010555.4

uniprot acc num :

P27931

ncbi mol weight :

Recombinant mouse IL-1 receptor type II (CD121b) is a protein consisting of 350 amino acid residue subunits, due to glycosylation migrates as an approximately 90 kDa protein on SDS-PAGE.

uniprot summary :

IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: membrane; plasma membrane; integral to membrane; extracellular region. Molecular Function: interleukin-1, Type II, blocking receptor activity; interleukin-1 receptor activity

size1 :

0.05 mg

price1 :

220 USD

size2 :

0.2 mg

price2 :

655

size3 :

1 mg

price3 :

2525

more info or order :

MyBioSource product webpage