Human IL-17RA (CD217) Fc tagged Recombinant | MyBioSource MBS553248 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human IL-17RA (CD217) Fc tagged Recombinant

catalog :

MBS553248

quantity :

0.05 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553248

products type :

Recombinant Protein

products full name :

Human IL-17RA (CD217) Fc tagged Recombinant

products short name :

IL-17RA (CD217) Fc tagged

products name syn :

Human IL-17 receptor Fc tag Recombinant; il-17ra; il17RA; interleukin-17 r

other names :

interleukin-17 receptor A; Interleukin-17 receptor A; CDw217

products gene name :

IL17RA

products gene name syn :

IL-17R

other gene names :

IL17RA; IL17R; IL-17 receptor A; IL-17RA

uniprot entry name :

I17RA_HUMAN

host :

HEk293 Cells

reactivity :

Measured by its ability to bind immobilized recombinant human IL-17A at a concentration range of 1-32ng/ml in a functional ELISA assay.

sequence length :

866

purity :

>98%, as determined by SDS-PAGE and HPLC

form :

Recombinant Interleukin-17 receptor alpha is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant IL-17 receptor alpha, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Host Note: Optimized DNA sequence encoding extracellular domain of human IL17R receptor including a C terminal Human IgG1 Fc tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant IL17RA/Fc is a homodimer protein consisting of 300 amino acid residue subunits, due to glycosylation migrates as an approximately 55kD protein under reducing SDS-PAGE conditions.

products categories :

Receptors CD

products description :

IL-17 is a potent regulator of the neutrophil response. Both IL-17A and IL-17F are capable of signaling through IL-17RA to induce granulopoietic factors such as G-CSF and stem cell factor which leads to expansion of neutrophil progenitors in the bone marrow and spleen, as well as expansion of mature neutrophils in peripheral blood. IL-17RA signaling up- regulates production of neutrophilic chemokines such as CXCL1 (KC), CXCL2, CXCL5, CXCL6, and CXCL8, which in turn regulate neutrophil emigration to mucosal sites. Due to this role in neutrophil expansion and recruitment, IL-17RA signaling is an important part of the host response to extracellular bacterial infections.To date, four additional receptors have been identified in the IL- 17R family based on sequence homology to IL-17R (IL- 17Rh1, IL-17RC, IL-17RD, and IL-17RE) and among them, IL- 17RC has been shown recently to physically associate with IL-17RA, suggesting that it may be a functional component in the IL-17R complex. Nevertheless, the final structure of the functional IL-17 receptor and the mechanisms of interactions with IL-17A remain unknown.

products references :

cloning and characterisation of rainbow trout interleukin (il) -17a/f2 and IL-17RA : expression during infection and bioactivity of the recombinant il-17a/f2. . Infect. Immun., Nov 2012; 10.1128/IAI.00599-12. the il-17a/ IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment . Circ. Res., Mar 2012; 110: 675 - 687. a cc' loop decoy peptide blocks the interaction between act1 and IL-17RA to attenuate il-17 and il-25 induced inflammation . Sci. Signal., Nov 2011; 4: ra72. lack of IL-17RA signalling prevents autoimmune inflammation of the joint and give rise to a th2-like phenotype in collagen-induced arthritis . Ann Rheum Dis, Mar 2011; 70: A50 - A51. il-17a- versus il-17f-induced intracellular signal transduction pathways and modulation by IL-17RA and il-17rc rna interference in rheumatoid synoviocytes . Ann Rheum Dis, Feb 2011; 70: 341 - 348.

ncbi gi num :

23238208

ncbi acc num :

NP_055154.3

ncbi gb acc num :

NM_014339.6

uniprot acc num :

Q96F46

ncbi mol weight :

96,122 Da

ncbi summary :

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

uniprot summary :

IL17RA: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 22q11.1. Cellular Component: integral to plasma membrane; extracellular region. Molecular Function: protein binding; interleukin-17 receptor activity. Biological Process: cell surface receptor linked signal transduction; positive regulation of interleukin-23 production; cytokine and chemokine mediated signaling pathway. Disease: Candidiasis, Familial, 5

size1 :

0.05 mg

price1 :

220 USD

size2 :

0.2 mg

price2 :

595

size3 :

1 mg

price3 :

2220

more info or order :

MyBioSource product webpage