Human TARC (CCL17) Recombinant | MyBioSource MBS553219 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

protein

product name :

Human TARC (CCL17) Recombinant

catalog :

MBS553219

quantity :

0.02 mg

price :

220 USD

product information

catalog number :

MBS553219

products type :

Recombinant Protein

products full name :

Human TARC (CCL17) Recombinant

products short name :

TARC (CCL17)

products name syn :

ccl-17 ; CCL17; tarc

other names :

C-C motif chemokine 17; C-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine

products gene name :

TARC

other gene names :

CCL17; SCYA17; TARC

uniprot entry name :

CCL17_HUMAN

host :

E Coli

sequence length :

sequence :

MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS

purity :

>98%, as determined by SDS-PAGE and HPLC

form :

Recombinant TARC was lyophilized from a 0.2 um filtered 20mM PB,100mM NaCl solution pH 7.5.

storage stability :

The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: IL8. Host Note: Optimized DNA sequence encoding Human TARC (CCL17) mature chain was expressed in Escherichia Coli.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Molecular Weight Note: Human CCL-17, generated by the proteolytic removal of the signal peptide. and propeptide and has a calculated molecular mass of approximately 8kDa. Recombinant TARC is a disulfide-linked monomeric protein consisting of 72 amino acid residue subunits and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.

products categories :

Cytokines

products description :

Thymus and activation- regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors binding TARC with high affinity and specificity.The chemokine TARC is a ligand for the chemokine receptor CCR4 expressed on T helper (Th) 2- type CD4 T cells.

products references :

il-12 produced by dendritic cells augments cd8+ t cell activation through the production of the chemokines ccl1 and CCL17 . J. Immunol., Dec 2008; 181: 8576 - 8584. clinical significance of serum tarc/ CCL17 in atll patients: high tarc/ CCL17 level is a significant unfavorable prognostic factor . Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 2821. respiratory syncytial virus synergizes with th2 cytokines to induce optimal levels of tarc/ CCL17 . J. Immunol., Aug 2007; 179: 1648 - 1658. circulating thymus- and activation-regulated chemokine/ CCL17 is a useful biomarker for discriminating acute eosinophilic pneumonia from other causes of acute lung injury . Chest, Jun 2007; 131: 1726 - 1734. evidence that phospholipase c-dependent, calcium-independent mechanisms are required for directional migration of t lymphocytes in response to the ccr4 ligands CCL17 and ccl22 . J. Leukoc. Biol., Jun 2006; 79: 1369 - 1380.

ncbi gi num :

4506829

ncbi acc num :

NP_002978.1

ncbi gb acc num :

NM_002987.2

uniprot acc num :

Q92583

ncbi mol weight :

10,507 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!GPCR Ligand Binding Pathway 161020!!IL4-mediated Signaling Events Pathway 137933!!Peptide Ligand-binding Receptors Pathway 106358!!Signaling By GPCR Pathway 106356

uniprot summary :

Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Ref.7. Subcellular location: Secreted. Tissue specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine. Induction: By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes. Sequence similarities: Belongs to the intercrine beta (chemokine CC) family. Caution: Was originally (Ref.6) thought to be a ligand for CCR8.

size :

0.02 mg

price :

220 USD