Human Resistin Recombinant | MyBioSource MBS553192 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Resistin Recombinant

catalog :

MBS553192

quantity :

0.005 mg

price :

145 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553192

products type :

Recombinant Protein

products full name :

Human Resistin Recombinant

products short name :

[Resistin]

products name syn :

[RETN; FIZZ3; HXCP1; RSTN; Resistin]

other names :

[resistin; Resistin; Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3]

products gene name :

[Resistin]

other gene names :

[RETN; FIZZ3; HXCP1; RSTN; ADSF]

uniprot entry name :

RETN_HUMAN

sequence length :

108

purity :

>95%, as determined by SDS-PAGE and HPLC

form :

Recombinant human Resistin was lyophilized from a 0.2 um filtered PBS solution.

storage stability :

The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2°-8° for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

other info1 :

Host Note: Optimized DNA sequence encoding Human Resistin mature chain was expressed in Escherichia Coli.

other info2 :

Biological Activity: Determined by its ability to stimulate lipolysis in cultured human adipocytes. Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. Molecular Weight Note: Native human Resistin, generated by the proteolytic removal of the signal peptide. and propeptide, the molecule has a calculated molecular mass of approximately 10 kDa. Recombinant Resistin is a disulfide-linked homodimeric protein consisting of two 93 amino acid residue subunits, and migrates as an approximately 20 kDa protein under non-reducing conditions and as a 10 kDa protein under reducing conditions in SDS-PAGE.

products categories :

Cytokines

products description :

Resistin was identified by screening for genes that are induced during the differentiation of adipocytes but down- regulated in mature adipocytes. Resistin gene expression is induced during the differentiation of adipocytes. Resistin circulates in mouse serum, and its level is increased markedly in obesity. Adipocytes secrete resistin as a unique signaling molecule that may be the hormone potentially linking obesity to type II diabetes, which is characterized by target- tissue resistance to insulin. TNF-alpha is a negative regulator of Resistin gene expression and inhibits Resistin mRNA expression and protein secretion by 70-90 % in 3T3-L1 adipocytes.

products references :

Resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways . Endocrinology, Oct 2009; 150: 4643 - 4652. Resistin : a newly identified chemokine for human cd4-positive lymphocytes . Cardiovasc Res, Sep 2009; 10.1093/cvr/cvp278. Resistin -like molecule- inhibits sglt-1 activity and enhances glut2-dependent jejunal glucose transport . Diabetes, Sep 2009; 58: 2032 - 2038. Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide . J. Clin. Endocrinol. Metab., Aug 2009; 94: 3051 - 3057. endoplasmic reticulum stress regulates adipocyte Resistin expression . Diabetes, Aug 2009; 58: 1879 - 1886.

ncbi gi num :

301129180

ncbi acc num :

NP_001180303.1

ncbi gb acc num :

NM_001193374.1

uniprot acc num :

Q9HD89

ncbi pathways :

Adipogenesis Pathway (198832)

ncbi summary :

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

uniprot summary :

resistin: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Belongs to the resistin/FIZZ family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: extracellular space; nucleus. Molecular Function: hormone activity. Biological Process: fat cell differentiation; response to mechanical stimulus; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell migration; positive regulation of synaptic transmission; aging; response to insulin stimulus. Disease: Diabetes Mellitus, Noninsulin-dependent

size1 :

0.005 mg

price1 :

145 USD

size2 :

0.025 mg

price2 :

220

more info or order :

MyBioSource product webpage