Human CD66a Recombinant (CEACAM1) | MyBioSource MBS553187 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human CD66a Recombinant (CEACAM1)

catalog :

MBS553187

quantity :

0.02 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553187

products type :

Recombinant Protein

products full name :

Human CD66a Recombinant (CEACAM1)

products short name :

CD66a (CEACAM1)

products name syn :

Human CD66a Recombinant (CEACAM1) ; cd66a BGP; BGP1; BGPI; CEACAM1 cd66

other names :

carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2; Carcinoembryonic antigen-related cell adhesion molecule 1; Biliary glycoprotein 1

products gene name :

CD66

other gene names :

CEACAM1; BGP; BGP1; BGP-1

uniprot entry name :

CEAM1_HUMAN

host :

HEk293 Cells

sequence length :

464

purity :

>95%, as determined by SDS-PAGE and HPLC

form :

Recombinant CD66a is supplied as a 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant CD66a, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding extracellular domain of human CD66a including a C-terminal 6His tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant human CD66a is a monomer protein consisting of 405 amino acid residue subunits, due to glycosylation migrates as an approximately 65-85 kDa protein on SDS-PAGE.

products categories :

Receptors CD

products description :

CD66a is a member of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. However, CD66a combines structural features of the immunoglobulin superfamily with functional properties of cadherins.The mechanism (s) by which CD66a transmits signals.are unclear. However, CD66a is phosphorylated on its cytoplasmic domain, largely on tyrosine with a lower level of phosphoserine, in neutrophils and colon cancer cells. While at least eight isoforms of CD66a derived from differential splicing have been described, only those isoforms with a long cytoplasmic tail can be phosphorylated on tyrosine. In addition, associated protein tyrosine kinase and phosphatase activities may be involved in CD66a signaling.

products references :

inhibition of t-cell activation by a ceacam1 ( CD66a ) peptide . Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 4917. ceacam1 ( CD66a ) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and akt-dependent pathway . J. Biol. Chem., Dec 2006; 281: 39179 - 39193. neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 ( CD66a ) -expressing human b cells and inhibits antibody production . Infect. Immun., Jul 2005; 73: 4171 - 4179. significance of the adhesion molecule ceacam1 ( CD66a ) as a prognostic factor for survival in patients with carcinomas of the lung . AACR Meeting Abstracts, Mar 2004; 2004: 1217. CD66a interactions between human melanoma and nk cells: a novel class i mhc-independent inhibitory mechanism of cytotoxicity . J. Immunol., Mar 2002; 168: 2803 - 2810.

ncbi gi num :

68161541

ncbi acc num :

NP_001020083.1

ncbi gb acc num :

NM_001024912.2

uniprot acc num :

P13688

ncbi mol weight :

57,560 Da

ncbi pathways :

EGFR1 Signaling Pathway (198782)

ncbi summary :

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

uniprot summary :

CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted. Protein type: Immunoglobulin superfamily; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane. Molecular Function: protein binding; protein homodimerization activity. Biological Process: integrin-mediated signaling pathway; cell migration; angiogenesis; homophilic cell adhesion; blood coagulation; leukocyte migration

size1 :

0.02 mg

price1 :

220 USD

size2 :

0.1 mg

price2 :

595

size3 :

0.5 mg

price3 :

2220

more info or order :

MyBioSource product webpage