Human CD32b Recombinant (FcgR2b) | MyBioSource MBS553152 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human CD32b Recombinant (FcgR2b)

catalog :

MBS553152

quantity :

0.02 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553152

products type :

Recombinant Protein

products full name :

Human CD32b Recombinant (FcgR2b)

products short name :

CD32b (FcgR2b)

products name syn :

Human CD32b Recombinant (Fcg RIIb) ; Human CD32b Recombinant (Fcgamma RIIb) ; cd32; cd-32; fcgr3a

other names :

low affinity immunoglobulin gamma Fc region receptor II-b isoform 2; Low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc-gamma RII-b

products gene name :

CD32

other gene names :

FCGR2B; CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b

uniprot entry name :

FCG2B_HUMAN

host :

HEk293 Cells

sequence length :

290

purity :

>95%, as determined by SDS-PAGE and HPLC

form :

Recombinant CD32b is supplied as a lyophilized 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant CD32b, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding Human extracellular domain of human CD32b including a C-terminal 6His tag was expressed in HEK293 cells. Biological Activity: The activity was determined by the ability to bind human IgG2 with a linear range of 0.1-6 ug/ml

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. Molecular Weight Note: Recombinant CD32b is a monomer protein consisting of 183 amino acid residue subunits, due to glycosylation migrates as an approximately 30 kDa protein on SDS-PAGE.

products categories :

Receptors CD

products description :

Human CD32B (Fc RIIB), the low-affinity inhibitory Fc receptor (Fc R), is highly homologous in its extracellular domain to CD32A (Fc RIIA), an activating Fc R.CD32B is coexpressed with activating Fc receptors on monocytes, macrophages, basophils and mast cells. CD32B is also expressed by B lymphocytes, the sole Fc R expressed by these cells, where it functions by countering B- cell receptor (BCR) -induced activation.

products references :

CD32b expression reflects phenotypic and functional heterogeneity in multiple myeloma (mm) . Blood (ASH Annual Meeting Abstracts), Nov 2008; 112: 842. CD32b is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody based therapy . Blood, Apr 2008; 111: 3403 - 3406. an fc-optimized monoclonal antibody against CD32b , the human inhibitory fc- receptor iib, in the immunotherapy of b-cell malignanacy. . Blood (ASH Annual Meeting Abstracts), Nov 2006; 108: 2529. CD32b on clonal plasma cells in systemic light-chain amyloidosis (al) and multiple myeloma (mm) : a target for immunotherapy in both disorders and a prognostic marker in mm. . Blood (ASH Annual Meeting Abstracts), Nov 2006; 108: 3489.

ncbi gi num :

50511932

ncbi acc num :

NP_001002273.1

ncbi gb acc num :

NM_001002273.2

uniprot acc num :

P31994

ncbi mol weight :

34,044 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway (366160); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)

ncbi summary :

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

uniprot summary :

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed. Protein type: Cell surface; Membrane protein, integral; Oncoprotein. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: integral to membrane; plasma membrane. Molecular Function: protein binding; IgG binding. Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction. Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To

size1 :

0.02 mg

price1 :

220 USD

size2 :

0.1 mg

price2 :

540

size3 :

0.5 mg

price3 :

2220

more info or order :

MyBioSource product webpage